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Investigations regarding the utility of prodigiosenes to treat leukemia
(2013)
Prodigiosenes, possessing a 4-methoxypyrrolyldipyrrin skeleton, are known for their anti-cancer
activity. Structural modification of the C-ring resulted in a series of prodigiosenes that displayed
promising activity against ...
Synthesis and characterisation of the unsubstituted dipyrrin and 4,4-dichloro-4-bora-3a,4a-diaza-s-indacene: improved synthesis and functionalisation of the simplest BODIPY framework
(2013)
An improved and scalable synthesis of the unsubstituted
4,4-difluoro-4-bora-3a,4a-diaza-s-indacene framework facilitates access to the previously unreported
parent dipyrrin HCl salt, as well as 4,4-dichloro-4-bora-3a,4a- ...
Conversion of F-BODIPYs to Cl-BODIPYs: Enhancing the Reactivity of F-BODIPYs
(2013-01)
A new method for the synthesis of Cl-BODIPYs from F-BODIPYs is reported, merely requiring
treatment of the F-BODIPY with boron trichloride. Cl-BODIPYs are exploited as synthetic
intermediates generated in situ for the ...
Synthesis and biological evaluation of prodigiosene conjugates of porphyrin, estrone and 4-hydroxytamoxifen
(Bioorganic & Medicinal Chemistry, 2013)
To generate the first series of prodigiosene conjugates, the tripyrrolic skeleton was appended to estrone, tamoxifen and porphyrin frameworks by way of ester linkers and various hydrocarbon chain lengths. The ability of ...