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Synthesis of Prodigiosene-Estrogen Conjugates: optimization of protecting group strategies and anticancer properties
(Canadian Journal of Chemistry, 2015)The tripyrrolic prodigiosene skeleton was conjugated to several estrogen ligands. The conjugation was achieved via an ester linker that proved to be unusually sensitive to hydrolysis during synthesis. This work describes ... -
The Acceptability of Deception in Pediatric Research
(Wolters Kluwer, 2015)Objective: Deception has been used to investigate the role of developmental and behavioral factors in child health; however, its acceptability for use in pediatric research has received little empirical attention. This ... -
Sex differences in experimental pain among healthy children: A systematic review and meta-analysis
(Lippincott Williams & Wilkins, 2014)Sex differences in response to experimental pain are commonly reported in systematic reviews in the adult literature. The objective of the present research was to conduct a systematic review and meta-analysis of sex ... -
Impact of threat level, task instruction, and individual characteristics on cold pressor pain and fear among children and their parents
(John Wiley & Sons, 2015)The cold pressor task (CPT) is increasingly used to induce experimental pain in children, but the specific methodology of the CPT is quite variable across pediatric studies. This study examined how subtle variations in CPT ... -
The epidemiology of chronic pain in children and adolescents revisited: A systematic review
(Wolters Kluwer, 2011)Chronic and recurrent pain not associated with a disease are very common in childhood and adolescence, but studies of pain prevalence have yielded inconsistent findings. This systematic review examined studies of chronic ... -
Cognitive Behavioural Therapy for Pediatric Chronic Pain: The Problem, Research, and Practice
(Springer, 2012)The purpose of this paper is to outline the rationale and use of cognitive-behavioural therapy (CBT) for the treatment of pediatric chronic pain. The paper begins by demonstrating the scope and impact of the problem of ... -
“Pain is not over when the needle ends”: A review and preliminary model of acute pain memory development in childhood
(Future Medicine Ltd, 2012)Over the past several decades, the field of pediatric pain has made impressive advances in our understanding of the pain experience of the developing child, as well as the devastating impact of inadequately managed pain ... -
Remembering the Pain of Childhood: Applying a Developmental Perspective to the Study of Pain Memories
(Lippincott Williams & Wilkins, 2015) -
When does pain matter? Acknowledging the subjectivity of clinical significance.
(Lippincott Williams & Wilkins, 2012) -
Lost in translation: A cautionary note about presentation of non-English measures in English language journals
(Wolters Kluwer Health, 2013) -
Dyadic analysis of child and parent trait and state pain catastrophizing in the process of children's pain communication
(Lippincott Williams & Wilkins, 2016)Explored separately, child and parent catastrophic thoughts about child pain show robust negative relations with child pain. The objective of this study was to conduct a dyadic analysis to elucidate intra- and inter-personal ... -
Regioselective Substituent Effects upon the Synthesis of Dipyrrins from 2-Formyl Pyrroles
(Canadian Journal of Chemistry, 2018)The synthesis of symmetric α-free meso-H-dipyrrin hydrobromides from 5-H-2-formyl pyrroles was investigated. The self-condensation produces regioisomeric dipyrrins through the adoption of two mechanistic pathways. The key ... -
Synthesis of symmetric meso-H dipyrrin hydrobromides from 2-formyl pyrroles
(Synlett, 2014)The reaction of 2-formyl pyrroles in acidic methanol gives the corresponding symmetric, meso-H 4,6-dipyrrin hydrobromides. This convenient strategy involves initial deformylation under the acidic conditions, followed by ... -
The Use of Tin (IV) Chloride to Selectively Cleave Benzyl Esters over Benzyl Ethers and Benzyl Amines
(Canadian Journal of Chemistry, 2014)Benzyl esters are cleaved upon reaction with SnCl4, resulting in isolation of the corresponding carboxylic acid. Importantly, benzyl ethers, amines and amides do not undergo debenzylation under these conditions, nor do a ... -
Antimicrobial Activity of Non-natural Prodigiosenes
(RSC Advances, 2013)Tripyrrolic prodigiosenes, derivatives of the natural product prodigiosin, have been produced via multi-step synthesis beginning with 2-formyl pyrroles bearing various functionalities at the 4-position. Two tin complexes ... -
Activation and Deprotection of F-BODIPYs using Boron Trihalides
(2014)The activation of F-BODIPYs with boron trihalides, followed by treatment with a nuclephile, effects facile substitution at boron; using water as the nucleophile promotes deprotective removal of the–BF2 moiety and thereby ... -
Synthesis and Characterization of Pyrrolyldipyrrin F-BODIPYs
(Photochemical and Photobiological Sciences, 2018)A series of synthetic analogs of the tripyrrolic natural product prodigiosin were complexed with boron trifluoride to generate the corresponding F-BODIPYs. The maximum wavelengths of absorption and emission of the ... -
Photo-induced Anticancer Activity and Singlet Oxygen Production of Prodigiosenes
(2018)The photo-induced cytotoxicity of prodigiosenes is reported. One prodigiosene represents a synthetic analogue of the natural product prodigiosin, and two are conjugated to molecules that target the estrogen receptor (ER). ... -
Synthesis and Reactivity of Aza-Dipyrrin Alkali Metal Salts
(Chemical Communications, 2018)We report the lithium, sodium and potassium salts of aza-dipyrrins and detail their use as anionic aza-dipyrrinato ligand sources in complexation. Of the three types of alkali salts studied, those of lithium are found to ... -
Current CaCO3 dissolution at the seafloor caused by anthropogenic CO2
(PNAS, 2018-10-29)Oceanic uptake of anthropogenic CO2 leads to decreased pH, carbonate ion concentration, and saturation state with respect to CaCO3 minerals, causing increased dissolution of these minerals at the deep seafloor. This ...
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