Browsing Pediatrics Faculty Research, Publications and Presentations by Submit Date
Now showing items 1-20 of 34
-
Tumor suppressor protein kinase Chk2 is a mediator of anoikis of intestinal epithelial cells
Resistance of carcinoma cells to anoikis, apoptosis that is normally induced by detachment of non-malignant epithelial cells from the extracellular matrix, is thought to be critical for carcinoma progression. Molecular ... -
Oncogenic ras-induced downregulation of a pro-apoptotic protease caspase-2 is required for malignant transformation of intestinal epithelial cells
Resistance of carcinoma cells to anoikis, apoptosis that is normally induced by loss of cell-to-extracellular matrix (ECM) adhesion, is thought to be essential for the ability of these cells to form primary tumors, invade ... -
Technologies of trust in epidemic response: openness, reflexivity and accountability during the 2014-2016 Ebola outbreak in West Africa
Trust is an essential component of successful cooperative endeavours. The global health response to the 2014–2016 West Africa Ebola outbreak confronted historically tenuous regional relationships of trust. Challenging ... -
Prepared for the “unexpected”? Lessons from the 2014-16 Ebola epidemic in West Africa on integrating emergent theory designs into outbreak response.
Summary Box 1. Even seemingly straightforward interventions, such as vaccine delivery, require real-time awareness of emergent on-the-ground local (‘field’) realities. 2. Outbreak response requires thoughtful engagement ... -
Substitute Decision Making About Research: Identifying the Legally Authorized Representative in Four Canadian Provinces
Canada's aging population presents new incentives for research on Alzheimer's and other forms of dementia. But the public interest in advancing knowledge about these diseases must be partnered with a concern for exploitation, ... -
Challenges to immunization: the experience of homeless youth
Background: Homelessness is a critical social issue, both a product of, and contributing to, poor mental and physical health. Over 150,000 young Canadians live on the streets. Homeless youth experience a high incidence of ... -
Global challenges of implementing human papillomavirus vaccines
Human Papillomavirus vaccines are widely hailed as a sweeping pharmaceutical innovation for the universal benefit of all women. The implementation of the vaccines, however, is far from universal or equitable. Socio- ... -
Rendre évident: une approche symétrique de la réglementation des produits thérapeutiques
ENGLISH: Within the social studies of science, risk regulation regimes dominated by a technocratic approach are critiqued for neglecting public, socially situated epistemological standpoints, which, it is argued, are more ...