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Universal intermittent properties of particle trajectories in highly turbulent flows
(2008-06)
We present a collection of eight data sets from state-of-the-art experiments and
numerical simulations on turbulent velocity statistics along particle trajectories
obtained in different flows with Reynolds numbers in ...
Development and validation of a sensitive and specific HPLC assay of cladribine for pharmacokinetics studies in rats
(2007)
PURPOSE: To develop and validate a sensitive and specific HPLC assay for cladribine
(CdA) in plasma for pharmacokinetic studies in rats. METHODS: CdA and the internal
standard AZT were purchased from Sigma-Aldrich Chem. ...
Lipophilic sugar nucleotide synthesis by structure-based design of nucleotidylyltransferase substrates
(2008-02)
Structure-based design of alkyl sugar-1-phosphates provides an efficient
nucleotidylyltransferase-catalyzed synthesis of a series of new lipophilic sugar nucleotides
possessing long or branched alkyl chains, thereby ...
Antimicrobial Activities of Jadomycin B and Structurally Related Analogues
(2009-03)
Natural products are leads for new antibiotics as a result of their structural complexity and
diversity. We have isolated a series of structurally related polyketide-derived natural products
from Streptomyces venezuelae ...
A Method for Structure-Activity Analysis of Quorum-Sensing Signaling Peptides from Naturally Transformable Streptococci
(2009-12)
Many species of streptococci secrete and use a competence-stimulating peptide (CSP) to initiate
quorum sensing for induction of genetic competence, bacteriocin production, and other activities.
These signaling molecules ...
Structure-activity analysis of quorum-sensing signaling peptides from Streptococcus mutans
(2007-02)
Streptococcus mutans secretes and utilizes a 21-amino-acid signaling peptide pheromone to
initiate quorum sensing for genetic competence, biofilm formation, stress responses, and bacteriocin
production. In this study, we ...
Exercise hemodynamic and neurohormone responses as sensitive biomarkers for diltiazem in rats
(2006-05)
Purpose. To investigate the potential of exercise hemodyanamic and neurohormone
variables as sensitive biomarkers for pre-clinical evaluation of diltiazem (DTZ).
Methods. Sprague Dawley (SD) rats were randomly divided ...
Evaluating the quality of randomized controlled trials that examine the efficacy of natural health products: a systematic review of critical appraisal instruments
(2009-12)
The purpose of this project was to conduct a systematic review to identify instruments designed to evaluate the quality of randomized controlled trials (RCTs) of natural health products (NHPs). Instruments were examined ...
The relationship between type of drug therapy and blood glucose self-monitoring test strips claimed by beneficiaries of the Seniors' Pharmacare Program in Nova Scotia, Canada
(2008)
BACKGROUND: The healthcare expenditure on self-monitoring of blood glucose (SMBG) test strips under the Nova Scotia Seniors' Pharmacare Program (NSSPP) has increased significantly in recent years. The objective of this ...
Evaluating the quality of randomized controlled trials that examine the efficacy of natural health products: a systematic review of critical appraisal instruments
(2009-12)
The purpose of this project was to conduct a systematic review to identify instruments designed to evaluate the quality of randomized controlled trials (RCTs) of natural health products (NHPs). Instruments were examined ...