Browsing Pharmacy by Title
Now showing items 1-20 of 25
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Antimicrobial Activities of Jadomycin B and Structurally Related Analogues
(2009-03)Natural products are leads for new antibiotics as a result of their structural complexity and diversity. We have isolated a series of structurally related polyketide-derived natural products from Streptomyces venezuelae ... -
Community engaged scholarship to catalyze innovation: a case study of the uptake of portable inhalers for respiratory medication in a pediatric emergency department in Nova Scotia
(Longwoods Publishing, 2016)This commentary, in response to Tamblyn et al. (2016), provides a case study of the uptake of metered-dose inhalers with spacers to deliver respiratory medication in a pediatric emergency department in Nova Scotia. Our ... -
Deprescribing Interventions in Primary Health Care Mapped to the Behaviour Change Wheel: A Scoping Review
(Elsevier, 2021-07)Background: Polypharmacy and inappropriate medication use are an increasing concern. Deprescribing may improve medication use through planned and supervised dose reduction or stopping of medications. As most medication ... -
Development and validation of a sensitive and specific HPLC assay of cladribine for pharmacokinetics studies in rats
(2007)PURPOSE: To develop and validate a sensitive and specific HPLC assay for cladribine (CdA) in plasma for pharmacokinetic studies in rats. METHODS: CdA and the internal standard AZT were purchased from Sigma-Aldrich Chem. ... -
Development and validation of the Chinese version of the Reintegration to Normal Living Index for use with stroke patients
(2011-02)OBJECTIVE: To develop and validate a Chinese version of the Reintegration to Normal Living Index. DESIGN: Descriptive case-series. SUBJECTS: Seventy-five individuals with chronic stroke and 55 age-matched healthy subjects. ... -
Drug Use Management and Policy Residency: A Service-Learning Application
(American Journal of Pharmaceutical Education, 2005)Objectives. To establish, implement, and evaluate a drug use management and policy residency program within the context of a service-learning framework. Design. Residents completed a 4-month term in which they were ... -
Elastase and Tryptase Govern TNF alpha-Mediated Production of Active Chemerin by Adipocytes
(2012-12)Chemerin is a leukocyte chemoattractant and adipokine with important immune and metabolic roles. Chemerin, secreted in an inactive form prochemerin, undergoes C-terminal proteolytic cleavage to generate active chemerin, a ... -
Embryonic lethality in mice lacking the nuclear factor of activated T cells 5 protein due to impaired cardiac development and function
(2011)Nuclear factor of activated T cells 5 protein (NFAT5) is thought to be important for cellular adaptation to osmotic stress by regulating the transcription of genes responsible for the synthesis or transport of organic ... -
Evaluating the quality of randomized controlled trials that examine the efficacy of natural health products: a systematic review of critical appraisal instruments
(2009-12)The purpose of this project was to conduct a systematic review to identify instruments designed to evaluate the quality of randomized controlled trials (RCTs) of natural health products (NHPs). Instruments were examined ... -
Evaluating the quality of randomized controlled trials that examine the efficacy of natural health products: a systematic review of critical appraisal instruments
(2009-12)The purpose of this project was to conduct a systematic review to identify instruments designed to evaluate the quality of randomized controlled trials (RCTs) of natural health products (NHPs). Instruments were examined ... -
Exercise hemodynamic and neurohormone responses as sensitive biomarkers for diltiazem in rats
(2006-05)Purpose. To investigate the potential of exercise hemodyanamic and neurohormone variables as sensitive biomarkers for pre-clinical evaluation of diltiazem (DTZ). Methods. Sprague Dawley (SD) rats were randomly divided ... -
Formation of a Collaborative Interprofessional Primary Healthcare Deprescribing Research Team in Nova Scotia
(2019-06)Study objective: To describe the development of a collaborative interprofessional primary health care deprescribing research team in Nova Scotia. Methods: Initiated by two College of Pharmacy faculty members, a core ... -
Impact of pharmacists as immunizers on vaccination rates: a systematic review and meta-analysis
(2016)Background: Underutilization of vaccination programs remains a significant public health concern. Pharmacists serve as educators, facilitators, and in some jurisdictions, as administrators of vaccines. Though pharmacists ... -
Incidence of Deep Vein Thrombosis in Hospitalized Chinese Medical Patients and the Impact of DVT Prophylaxis
(2011)Objective. To evaluate the incidence of deep vein thrombosis in hospitalized Chinese medical patients and the impact of DVT prophylaxis. Methods. All cases of confirmed proximal DVT from 1 January 2005 to 31 December ... -
Introductory Medicinal Chemistry for Pharmacy Students: An Assignment-Based Online Assessment Strategy (Postprint)
(ACS Publications, 2024-06-22)New assessment approaches for medicinal chemistry in an introductory course within the pharmacy curriculum are presented. A required introductory pharmaceutical sciences course specific for first year entry-to-practice ... -
Key Priorities to Implement Deprescribing in Primary Health Care in Nova Scotia: Results from the Deprescribing in Primary Health Care in Nova Scotia Knowledge Exchange Event (June 20, 2019)
(2020-03-03)Inappropriate medication use and polypharmacy are associated with increased adverse drug reactions, hospitalizations and mortality. Deprescribing has been found to decrease the use of medications and medication costs and ... -
Lipophilic sugar nucleotide synthesis by structure-based design of nucleotidylyltransferase substrates
(2008-02)Structure-based design of alkyl sugar-1-phosphates provides an efficient nucleotidylyltransferase-catalyzed synthesis of a series of new lipophilic sugar nucleotides possessing long or branched alkyl chains, thereby ... -
Measuring Knowledge Translation Uptake Using Citation Metrics: A Case Study of a Pan-Canadian Network of Pharmacoepidemiology Researchers
(Taylor & Francis, 2016)ABSTRACT Collecting citation metric data is important, as research funders are increasingly demanding impact assessment, but there is limited consensus on the most rigorous and accurate approach. We compared three ... -
A Method for Structure-Activity Analysis of Quorum-Sensing Signaling Peptides from Naturally Transformable Streptococci
(2009-12)Many species of streptococci secrete and use a competence-stimulating peptide (CSP) to initiate quorum sensing for induction of genetic competence, bacteriocin production, and other activities. These signaling molecules ...