dc.contributor.author | Hassan, Fahima | |
dc.date.accessioned | 2024-01-10T14:25:48Z | |
dc.date.available | 2024-01-10T14:25:48Z | |
dc.date.issued | 2024-01-08 | |
dc.identifier.uri | http://hdl.handle.net/10222/83374 | |
dc.description.abstract | This study investigated the association between acute SARS-CoV-2, influenza, respiratory syncytial virus (RSV), enterovirus/rhinovirus infections, and hospitalization for febrile seizures in children aged <7 years. Conducted in 11 Canadian Immunization Monitoring Program-Active (IMPACT) centers from Aug 2021 to Dec 2022, the prospective surveillance included 3,306 subjects with febrile seizures. The association was measured with a cohort study design and mixed-effects logistic regression. While 18% required hospitalization, differential testing for SARS-CoV-2 (87% hospitalized vs. 26% non-hospitalized) revealed significant bias. Hospitalization with febrile seizure and SARS-COV-2 testing varied across IMPACT centers and during the Omicron period. Adjusting for confounders, the study could not validly estimate the association due to extensive misclassification bias in non-hospitalized cases. Limited testing in non-hospitalized patients highlighted the need for a more systematic approach, while variations in hospitalization and testing practices underscored the importance of exploring and addressing these discrepancies in future research. | en_US |
dc.language.iso | en | en_US |
dc.subject | SARS-CoV-2 | en_US |
dc.subject | Febrile seizure | en_US |
dc.subject | pediatric | en_US |
dc.title | ESTIMATING THE ASSOCIATION BETWEEN ACUTE SARS-CoV-2 AND FEBRILE SEIZURE IN CHILDREN USING THE CANADIAN IMMUNIZATION MONITORING PROGRAM-ACTIVE (IMPACT) | en_US |
dc.date.defence | 2023-12-19 | |
dc.contributor.department | Department of Community Health & Epidemiology | en_US |
dc.contributor.degree | Master of Science | en_US |
dc.contributor.external-examiner | n/a | en_US |
dc.contributor.thesis-reader | George Kephart | en_US |
dc.contributor.thesis-reader | Julie A Bettinger | en_US |
dc.contributor.thesis-supervisor | Karina Top | en_US |
dc.contributor.thesis-supervisor | Cindy Feng | en_US |
dc.contributor.ethics-approval | Received | en_US |
dc.contributor.manuscripts | Not Applicable | en_US |
dc.contributor.copyright-release | Not Applicable | en_US |