Faculty of Graduate Studies Online Theses

Improved Synthesis and Enhanced Reactivity of X-BODIPYs

Lundrigan, Travis

F-BODIPYs are most known for their high thermal and photochemical stability, being quite chemically robust and having tunable fluorescence properties. This thesis focuses on three general areas of BODIPY chemistry: the ...

Living in "No Peace--No War": Fluctuating Governance Among Armed Actors in the eastern Democratic Republic of the Congo

Suarez, Carla

There is growing recognition among academics and practitioners that civilians play a critical role in armed conflict. Even if constrained to varying degrees and in varying forms, they make tactical decisions and develop ...

Understanding the Loss of Capture during Mechanical Pacing

Taeb, Behzad

Pacemakers are a corner-stone of modern heart rhythm management. However, restrictions and complications motivate exploration of alternative pacing modes. Mechanical stimulation can cause excitation, but pacing capture ...

The role of mast cells and toll-like receptor 2 (TLR2) in host defence and pathology following Chlamydia infection

Shantz, Emily

Chlamydia trachomatis (Ct) is the most common bacterial sexually transmitted infection and the leading cause of infectious blindness worldwide. A comprehensive understanding of immune responses to Ct, and how they lead to ...

STUDY OF JADOMYCIN PHARMACOKINETICS AND ANTI-BREAST CANCER ACTIVITY IN BALB/C MICE

Relja, Nicholas

Breast cancer is the most common form of cancer in Canadian women. Despite numerous therapeutic options, multidrug resistance (MDR) remains an obstacle to successful therapy. Jadomycins are natural products derived ...

LOCOMOTION CHARACTERIZATION OF DCC AND NCK2 MUTANT MICE

Li, Qingyu

ABSTRACT Transmembrane receptor protein DCC (deleted in colorectal cancer) and its intracellular binding partner Nck (non-catalytic tyrosine kinase adaptor protein) are both important in spinal locomotor network formation. ...

In Vitro Toxicological Evaluation of Airborne Copper-based Nanoparticles

Burns, Eileen

A knowledge gap exists concerning the role of metal and metal oxide composition in explaining adverse pulmonary and cardiovascular health effect associations found with inhaled nanoparticles (NPs). This research investigated ...

Evaluation of Sugar Biosynthetic Enzymes and Studies on Jadomycin Biosynthesis

Forget, Stephanie M.

Carbohydrates are ubiquitous in biological systems, possessing diversity in terms of both structure and function. Studies pertaining to bacterial enzymes that recognize and process carbohydrates in cell wall biosynthesis ...

DEVELOPMENT AND ASSESSMENT OF A NEW SOLUTION FOR CARBON DIOXIDE REMOVAL FROM ANAESTHESIA REBREATHING CIRCUITS

Wilfart, Florentin Michael

Background: Our aging population’s rising health care costs cannot be met by the limited numbers of young tax payers. Compounding the cost of surgery are the costs associated with post operative cognitive decline (POCD) ...

Effects of Surface Structure on the Electrocatalytic Activity of Pt-based Nanoparticles: An X-ray Absorption Spectroscopy Study

Duchesne, Paul Nicholson

With clean and renewable sources of energy being a major focus for modern societies, developing efficient means of energy storage is a necessity. Of the technologies currently available, electrochemical fuel cells stand ...

Design of piezoelectric oscillometry, accuracy in tracking time-varying impedance and implications on the frequency dependence of resistance

hanafialamdari, Hamed

Oscillometry (OS) is commonly performed by actuators that are heavy and bulky. In this thesis I designed and simulated a new single frequency OS system. This novel design used a piezoelectric bimorph actuator on resonance. ...

X-ray Absorption Spectroscopy Studies of Thiolate-protected Gold Nanoclusters with FCC-, HCP- and BCC-like Core Geometry

Yang, Rui

Research on thiolate-protected gold nanoclusters (AuSR NCs) has recently attracted a great deal of interests due to their intriguing atomic structure and promising applications in catalysis, nanoelectronics, bio-detection, ...

THE ROLE OF THE PHYSICAL IN AUGUSTINE’S RETURN TO GOD IN THE CONFESSIONES

Wollf, Justin

The role of the physical in the Trinitarian cosmos of the Confessiones demonstrates the natural capacity of the human to return to God by, and with, physical bodies. The physical is the relative basis and beginning of ...

A FRAMEWORK FOR LOGISTICS MANAGEMENT IN THE CLINICAL TRIALS INDUSTRY: AN EXTENSION OF THE STATE-OF-THE ART USING CONTEMPORARY SOFTWARE ARCHITECTURES AND TOOLS

Sadoon, Emad

Logistics management in the clinical trials industry is a very challenging undertaking due to multiple stakeholders, complex processes, diverse software applications, intensive white-collar jobs, and onerous quality ...

PARTICIPATORY DESIGN RESEARCH TO INTEGRATE PRIVACY LAW REQUIREMENTS AS DESIGN REQUIREMENTS FOR PATIENT PORTAL USER INTERFACE

Aljohani, Maha

The increase in privacy legislation has motivated our research on integrating privacy law requirements as design requirements. An effective privacy compliance framework requires communication between privacy professionals ...

Use of nanoparticles (HPPS) to carry Curcumin to induce Heme Oxygenase-1 (HO-1) as a cytoprotective agent in human endothelial cells

Rasul, Amna

High-density lipoproteins (HDL) are endogenous nanoparticles that maintain physiological levels of low-density lipoprotein (LDL) via reverse cholesterol transport (RCT). HDL is known to reduce atherosclerotic lesions, ...