Faculty of Graduate Studies Online Theses: Recent submissions
Now showing items 1-20 of 5985
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Expanding the Scope of Nickel-Catalyzed C(sp2)–N/O Cross-Coupling Reactions Using Tailored Ancillary Ligands
The ubiquity of aryl C–N/O bonds in pharmaceuticals and natural products necessitates the development of robust and selective methodologies to construct such linkages efficiently. Palladium-catalyzed C(sp2)–N/O cross-coupling ... -
The Role of PRP4K as a Tumor Suppressor in Lewis Lung Carcinoma Cells
Although originally identified as a splicing kinase, recent data indicates that pre-mRNA processing factor kinase 4 (PRP4K) may promote metastasis by a partial epithelial-to mesenchymal transition (EMT) phenotype. Thus, ... -
Loss of PRP4K is linked to anoikis resistance and partial epithelial-to-mesenchymal transition
Metastatic disease is the primary cause of cancer-related death, and as a result the metastatic potential of a tumor is an important indicator of patient survival. For tumor cells to metastasize, they must overcome a special ... -
Biomechanics of forward skating in ice hockey
The purpose of this thesis was to conduct a biomechanical analysis of hockey players skating at top speed in a direct line. Fourteen subjects from four different levels of ice hockey competition were chosen for this ... -
RESPONSIBLE BUSINESS CONDUCT IN THE EXTRACTIVE INDUSTRIES: PROSPECT OF RESPECTING WOMEN'S HUMAN RIGHTS IN GHANA
Business operations in the extractive industries (EI) continue to violate women’s human rights and the environment in the communities in which they operate. In Ghana, existing laws and regulations do not preclude businesses ... -
THE TRANSITION FROM ‘PAID PC/CONSOLE GAMES’ TO ‘FREEMIUM MOBILE GAMES’: FOCUSING ON USERS’ REACTIONS TO AND PRICE TOLERANCE OF IN-APP PURCHASE ITEMS
This study examines how customers react to online games that transition from being ‘Paid PC/console Games to ‘Freemium Mobile Games in the context of the game series “Diablo”. In particular, this study focuses on three ... -
AN EMPIRICAL STUDY ON THE ADOPTION OF MOBILE NEWS ARTICLES: FOCUSING ON HEURISTIC AND SYSTEMATIC CUES OF CURATED MOBILE NEWS APPS
Online curated news apps, such as Inshorts, have been becoming increasingly popular, largely because they provide users with the highlights of news articles that have been specifically selected for them. Each curated news ... -
RÉSISTANCE IDENTITAIRE DANS « BEAU TRAVAIL » DE CLAIRE DENIS : LE CADRE ET LE FANTÔME
Claire Denis is well known for her mysterious films, which often provoke controversy, and for her broad choice of topics, even though her movies more often than not revolve around the same themes (solitude, identity, desire, ... -
Experimental Investigation for the Particle and Sample Size Effect on the Shear Strength Parameters of Tire Derived Aggregate (TDA)
TDA has been successfully used in different civil engineering projects as a fill material in its pure state or mixed with soils in TDA-soil mixtures. Despite the superior geotechnical properties and successful applications ... -
Developing a Sustainable Bioprocess for Chitin Extraction from Atlantic Lobster Shell Waste
The goal of this research was to develop a fermentative chitin extraction method from Atlantic lobster shell waste. Results showed initial inoculum ratio was the most statistically significant variable in chitin extraction ... -
Identification of Roles for Arabidopsis thaliana RING-Type Ubiquitin Ligase XBAT35.2 and its Substrate Accelerated Cell Death11 (ACD11) in Abiotic Stress Tolerance
To survive adverse environmental conditions plants utilize various mechanisms including the production of the hormone abscisic acid, which promote cellular changes to ameliorate the negative effects of abiotic stress. The ... -
MICRORNA SPECIES REGULATE IMMUNE PROCESSES: A FOCUS ON NK CELLS IN CHRONIC ARTHRITIS
Rheumatoid arthritis (RA) is a common chronic autoimmune/inflammatory disease involving innate/adaptive lymphocytes and soluble mediators. Natural killer (NK) cells are innate lymphocytes that direct immunity through ... -
N and O isotope ratios of NO3- as a tracer for nitrogen cycling and water mass distribution
Nitrogen plays a central role in marine biogeochemistry. Its distribution, chemical speciation and ratio relative to other nutrients governs the presence and abundance of microbial communities, and of large scale ocean ... -
RALOXIFENE SENSITIZES GLIOBLASTOMA CELLS TO HYPOXIA -INDUCED DEATH THROUGH INHIBITION OF STRESS GRANULE DISSOLUTION
Glioblastoma multiforme (GBM) is the most common primary malignant brain tumour and carries a uniformly poor prognosis. Despite aggressive therapy, median survival is only 14 months. Death typically results from treatment ... -
Identification of Factors Regulating Cytoplasmic and Nuclear Lipid Droplets
Lipid droplets (LDs) are cellular metabolic energy reservoirs composed of a neutral lipid core of triglycerides (TG) and cholesterol esters (CE) that is surrounded by a surface monolayer of phospholipids and embedded ... -
DEVELOPING A TWO-PRONGED DRUG SCREEN TO IDENTIFY COMPOUNDS THAT PROTECT AGAINST CISPLATIN-INDUCED OTO- AND NEPHROTOXICITY
Cisplatin is a chemotherapy used to treat a variety of cancers, including several pediatric malignancies. Cancer survivors are plagued by lifelong cisplatin-induced toxicities, including kidney damage and ototoxicity, or ... -
SURPRISING IMPROVEMENTS IN LITHIUM ION AND SODIUM ION BATTERY CYCLE LIFE
Lithium ion battery research attracts much attention because lithium ion batteries have such extensive applications. Sodium ion batteries are an emerging field because of the sustainability of Na vs Li. However, issues ... -
Evaluating the Role of the COP9 Signalosome and Neddylation during Cytokinesis and in Response to DNA Damage
The covalent attachment of the ubiquitin-like protein NEDD8 via lysine residues on target proteins, termed neddylation, regulates the activity and stability of numerous proteins, particularly through regulating the activity ... -
Glycosphingolipid Metabolism and the Glycosphingolipid-Metabolizing Enzyme Beta-Glucosidase 2: Biochemical and Cell Biological Studies
Glycosphingolipids (GSLs) are constituents of eukaryotic cell membranes and consist of a lipid (ceramide) linked to one or more sugar residues. GSLs occur in many structurally distinct forms, varying in both their lipid ... -
Whose Reality Counts? Valuing Dalitbahujan Knowledge in a Technocratic India
Indian society is being reconfigured by the mobilization of people who had historically been marginalized in economic, social and cultural life. These people are referred to the constitution as Scheduled Tribes (ST), ...
