dc.contributor.author | Simmons, Maria | |
dc.date.accessioned | 2019-12-12T15:57:13Z | |
dc.date.available | 2019-12-12T15:57:13Z | |
dc.date.issued | 2019-12-12T15:57:13Z | |
dc.identifier.uri | http://hdl.handle.net/10222/76777 | |
dc.description.abstract | Dissociation is characterized by either heightened sensitivity to emotions (under-modulation) or dampened experience of emotions (over-modulation) (Krause-Utz & Elzinga, 2018; Lanius et al., 2010). Within fMRI studies, over- and under-modulation have been associated with differing functional connectivity when patients are exposed to memories of traumatic events (Krause-Utz et al., 2018; Ludӓscher et al., 2010; Winter et al., 2016). This study included female patients with Borderline Personality Disorder taking part in a 6-week treatment program to examine the interactions between changes in symptoms (n=13) and connectivity (n=12) pre- and post-treatment. Results suggest all symptom measures had significant changes from pre- to post-treatment. Changes in symptoms did not relate to changes of functional connectivity from pre- to post-treatment, but differing neurobiology was observed between under- and over-modulation. Furthermore, the amygdala appears to be co-activated with the nucleus accumbens, hippocampus, postcentral gyrus, dorsolateral middle temporal gyrus and precentral gyrus during mood induction tasks. | en_US |
dc.language.iso | en | en_US |
dc.subject | Borderline Personality Disorder | en_US |
dc.subject | Functional Connectivity | en_US |
dc.subject | fMRI | en_US |
dc.subject | Symptom Severity | en_US |
dc.title | FUNCTIONAL CONNECTIVITY, SYMPTOM SEVERITY AND TREATMENT OUTCOMES IN WOMEN WITH BORDERLINE PERSONALITY DISORDER | en_US |
dc.date.defence | 2019-12-02 | |
dc.contributor.department | Department of Psychiatry Research | en_US |
dc.contributor.degree | Master of Science | en_US |
dc.contributor.external-examiner | Dr. Derek Fisher | en_US |
dc.contributor.graduate-coordinator | Dr. Sherry Stewart | en_US |
dc.contributor.thesis-reader | Dr. Joel Town | en_US |
dc.contributor.thesis-reader | Dr. Aaron Newman | en_US |
dc.contributor.thesis-supervisor | Dr. Phil Tibbo | en_US |
dc.contributor.thesis-supervisor | Dr. Jackie Kinley | en_US |
dc.contributor.ethics-approval | Received | en_US |
dc.contributor.manuscripts | Not Applicable | en_US |
dc.contributor.copyright-release | Not Applicable | en_US |