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dc.contributor.authorNix, Hayden
dc.date.accessioned2018-07-19T11:28:27Z
dc.date.available2018-07-19T11:28:27Z
dc.identifier.urihttp://hdl.handle.net/10222/74063
dc.description.abstractPolyphosphate glass microspheres (PGM) are currently under development for application in transarterial chemoembolization (TACE), the standard of care treatment for intermediate stage hepatocellular carcinoma. PGMs are radiopaque, hemostatic, and resorbable. This thesis investigates the compatibility of doxorubicin (DOX), a chemotherapeutic, with this PGM system. A process was developed to synthesize PGMs that were efficiently loaded with DOX, spherical in nature, and in the clinically relevant size range. DOX release and PGM degradation were assessed as a function of elution media pH, PGM composition, and %DOX loading. In vitro cytocompatibility of PGM degradation products and the pharmacological activity of released DOX were also evaluated. Composition, therapeutic loading, and pH minimally affected PGM degradation. DOX release was mediated by eluant pH, and was highly linear while appearing to retain its pharmacological activity. However, PGM degradation products were also found to be cytotoxic. Overall, this PGM system shows promise as a TACE device.en_US
dc.language.isoenen_US
dc.subjectCanceren_US
dc.subjectDrug Releaseen_US
dc.subjectPolyphosphateen_US
dc.titleDoxorubicin Loaded Polyphosphate Glass Microspheres for Transarterial Chemoembolizationen_US
dc.typethesis
dc.date.defence2018-06-21
dc.contributor.departmentDepartment of Biomedical Engineeringen_US
dc.contributor.degreeMaster of Applied Scienceen_US
dc.contributor.external-examinerDr. John Framptonen_US
dc.contributor.graduate-coordinatorDr. Rob Adamsonen_US
dc.contributor.thesis-readerDr. Daniel Boyden_US
dc.contributor.thesis-readerDr. Paul Gratzeren_US
dc.contributor.thesis-readerDr. Bob Abrahamen_US
dc.contributor.thesis-supervisorDr. Mark Filiaggien_US
dc.contributor.ethics-approvalReceiveden_US
dc.contributor.manuscriptsNot Applicableen_US
dc.contributor.copyright-releaseNot Applicableen_US
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