dc.contributor.author | Bernard, Megan M | |
dc.date.accessioned | 2013-08-16T14:54:04Z | |
dc.date.available | 2013-08-16T14:54:04Z | |
dc.date.issued | 2013-08-16 | |
dc.identifier.uri | http://hdl.handle.net/10222/35356 | |
dc.description.abstract | [6]-Gingerol, [8]-gingerol, and [10]-gingerol are phytochemical extracts from ginger that are thought to contribute to its health-benefitting properties. The objectives of this investigation were to explore and compare the in vitro anti-proliferative and cytotoxic effects of [6]-, [8]-, and [10]-gingerol on human and mouse mammary carcinoma cells, as well as their ability to inhibit T cell proliferation. [8]-Gingerol and [10]-gingerol induced mammary carcinoma cell death that did not require ROS production or caspase activation. All three gingerols inhibited the proliferation of mammary carcinoma cells and T cells, and the production of IFN-? by T cells. The production of IL-2 and the expression of early T cell activation markers, CD25 and CD69, were significantly decreased by [8]- and [10]-gingerol. The results demonstrated that [10]-gingerol was the most potent, followed by [8]-gingerol, then [6]-gingerol. Consequently, [8]- and [10]-gingerol warrant further investigation for the treatment of breast cancer and the control of inflammation. | en_US |
dc.language.iso | en_US | en_US |
dc.subject | T cells, breast cancer, phytochemicals, gingerol | en_US |
dc.title | A Comparative Study of the Anti-Breast Cancer and Immunomodulatory Effects of [6]-, [8]-, and [10]-Gingerol | en_US |
dc.date.defence | 2013-07-16 | |
dc.contributor.department | Department of Pathology | en_US |
dc.contributor.degree | Master of Science | en_US |
dc.contributor.external-examiner | n/a | en_US |
dc.contributor.graduate-coordinator | Dr. Wenda Greer | en_US |
dc.contributor.thesis-reader | Dr. Brent Johnston | en_US |
dc.contributor.thesis-reader | Dr. Jun Wang | en_US |
dc.contributor.thesis-reader | Dr. Robert Liwski | en_US |
dc.contributor.thesis-reader | Dr. Marianne Stanford | en_US |
dc.contributor.thesis-supervisor | Dr. David Hoskin | en_US |
dc.contributor.ethics-approval | Not Applicable | en_US |
dc.contributor.manuscripts | Not Applicable | en_US |
dc.contributor.copyright-release | Not Applicable | en_US |