dc.contributor.author | Rendon, Ricardo Andres | |
dc.date.accessioned | 2012-08-23T17:20:57Z | |
dc.date.available | 2012-08-23T17:20:57Z | |
dc.date.issued | 2012-08-23 | |
dc.identifier.uri | http://hdl.handle.net/10222/15337 | |
dc.description.abstract | Objective: To develop a predictive model for preoperative differentiation between benign (B) and malignant (M) histology in patients with renal masses (RM) using recursive partitioning.
Methods: We analyzed preoperative patient and tumour characteristics in 395 subjects who had surgery for RM suspicious for renal cell carcinoma.
Results: The model predicted B vs. M histology with an overall accuracy of 89.6% (95% CI 86.2,92.5). It assigned patients with smaller tumours (<5.67cc) and a predominantly (>45%) exophytic component a high risk of B disease (52.6%). Patients with symptoms, larger tumours (>5.67cc) and larger endophytic component (>35%) have a 0% risk of B disease.
Conclusion: B vs. M disease can be predicted accurately. This predictive accuracy is higher than that shown in renal biopsy series. It is hypothesized that for smaller and exophytic RMs, a biopsy is indicated. Symptomatic, larger and endophytic RMs should be removed without further investigations. | en_US |
dc.language.iso | en | en_US |
dc.subject | Renal cell carcinoma | en_US |
dc.subject | Renal mass | en_US |
dc.subject | prediction | en_US |
dc.subject | Classification tree | en_US |
dc.title | A PRE-OPERATIVE PREDICTIVE MODEL FOR THE CLASSIFICATION OF NEWLY DIAGNOSED RENAL MASSES LESS THAN 5 CM IN DIAMETER AS BENIGN OR MALIGNANT | en_US |
dc.date.defence | 2012-08-15 | |
dc.contributor.department | Department of Community Health & Epidemiology | en_US |
dc.contributor.degree | Master of Science | en_US |
dc.contributor.external-examiner | N/A | en_US |
dc.contributor.graduate-coordinator | Kathleen MacPherson | en_US |
dc.contributor.thesis-reader | Andreou Pantelis | en_US |
dc.contributor.thesis-supervisor | Mohamed Abdolell and Susan Kirkland | en_US |
dc.contributor.ethics-approval | Received | en_US |
dc.contributor.manuscripts | No | en_US |
dc.contributor.copyright-release | No | en_US |