A Knowledge Management Framework to Develop, Model, ALign and Operationalize Clinical Pathways to Provide Decision Support for Comorbid Diseases

Abstract

The objective of this thesis is to formalize, model, align and operationalize the evidence-based clinical algorithms of co-morbid chronic heart failure (CHF) and atrial fibrillation (AF) in order to provide clinical recommendations, care coordination and decision support to general practitioners (GPs). This thesis addresses following healthcare knowledge modeling issues: (a) modeling of healthcare knowledge, especially in terms of clinical guidelines and clinical pathways, to develop an ontology-based knowledge model for handling co-morbid diseases; (b) computerization of clinical pathways to offer point-of-care decision support; (c) alignment of ontologically-modeled disease-specific clinical pathways to handle co-morbid diseases; and (d) the provision of computerized decision support to GPs, based on modeled clinical guidelines and pathways, to assist them in handling co-morbid diseases. An elaborate OWL CP ontology for co-morbid CHF and AF was developed that can be executed to support the diagnosis and management of co-morbid CHF and AF in a general practice setting.