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dc.contributor.authorDoucet, Jensen
dc.date.accessioned2019-11-28T15:42:50Z
dc.date.available2019-11-28T15:42:50Z
dc.identifier.urihttp://hdl.handle.net/10222/76683
dc.description.abstractTransarterial embolization (TAE) is a minimally invasive procedure proven to reduce health care costs and recovery times while maximizing quality of life for patients. Next generation microspheres for TAE are required to be degradable and exhibit multi-modal imageability. Accordingly, two series of borate networks were investigated as candidate degradable radiopaque embolic agents for use in uterine artery embolization (UAE). The effect of substitutions of SrO or Ga2O3 for Rb2O on the structure and properties of borate networks was evaluated using density, differential scanning calorimetry, 11B MAS-NMR, mass loss, CT and MRI experiments. The glasses exhibited high radiopacities (over 3200 HU) and various degradation timeframes (from under 6 hours to over 48 hours). To assess the safety and efficacy of novel degradable, imageable microsphere for use in UAE an in vivo animal study protocol was developed. Additionally, an in vitro methodology was developed to objectively assess the risk of migration.en_US
dc.language.isoen_USen_US
dc.subjectGlassen_US
dc.subjectBioglassen_US
dc.subjectTransarterial Embolizationen_US
dc.subjectBorate Glassen_US
dc.titleSYNTHESIS, CHARACTERIZATION, AND RISK ASSESSMENT PLANNING FOR NOVEL DEGRADABLE AND IMAGEABLE EMBOLIC AGENTSen_US
dc.date.defence2018-06-25
dc.contributor.departmentDepartment of Biomedical Engineeringen_US
dc.contributor.degreeMaster of Applied Scienceen_US
dc.contributor.external-examinerDr. Paul Gratzeren_US
dc.contributor.graduate-coordinatorDr. Robert Adamsonen_US
dc.contributor.thesis-readerDr. Mark Filiaggien_US
dc.contributor.thesis-readerDr. Steven Beyeaen_US
dc.contributor.thesis-readerDr. Robert J Abrahamen_US
dc.contributor.thesis-supervisorDr. Daniel Boyden_US
dc.contributor.ethics-approvalReceiveden_US
dc.contributor.manuscriptsNot Applicableen_US
dc.contributor.copyright-releaseNot Applicableen_US
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