Browsing Jakeman, David by Submit Date
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Antimicrobial Activities of Jadomycin B and Structurally Related Analogues
Natural products are leads for new antibiotics as a result of their structural complexity and diversity. We have isolated a series of structurally related polyketide-derived natural products from Streptomyces venezuelae ... -
Lipophilic sugar nucleotide synthesis by structure-based design of nucleotidylyltransferase substrates
Structure-based design of alkyl sugar-1-phosphates provides an efficient nucleotidylyltransferase-catalyzed synthesis of a series of new lipophilic sugar nucleotides possessing long or branched alkyl chains, thereby ... -
Structure-activity analysis of quorum-sensing signaling peptides from Streptococcus mutans
Streptococcus mutans secretes and utilizes a 21-amino-acid signaling peptide pheromone to initiate quorum sensing for genetic competence, biofilm formation, stress responses, and bacteriocin production. In this study, we ... -
A Method for Structure-Activity Analysis of Quorum-Sensing Signaling Peptides from Naturally Transformable Streptococci
Many species of streptococci secrete and use a competence-stimulating peptide (CSP) to initiate quorum sensing for induction of genetic competence, bacteriocin production, and other activities. These signaling molecules ... -
Synthesis of a novel fluorinated phosphonyl C-glycoside, (3-deoxy-3-fluoro- F β-d-glucopyranosyl)methylphosphonate, a potential inhibitor of β- phosphoglucomutase Postprint
β-phosphoglucomutase (βPGM) catalyzes the conversion of β-glucose 1-phosphate (βG1P) to glucose-6-phosphate (G6P), a universal source of cellular energy, in a two-step process. Transition state analogue (TSA) complexes ... -
Introductory Medicinal Chemistry for Pharmacy Students: An Assignment-Based Online Assessment Strategy (Postprint)
New assessment approaches for medicinal chemistry in an introductory course within the pharmacy curriculum are presented. A required introductory pharmaceutical sciences course specific for first year entry-to-practice ...