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ENCAPSULATION OF BIOACTIVE SALMON PROTEIN HYDROLYSATES WITH CHITOSAN-COATED LIPOSOMES

dc.contributor.authorLi, Zhiyu
dc.contributor.copyright-releaseNot Applicableen_US
dc.contributor.degreeMaster of Scienceen_US
dc.contributor.departmentDepartment of Process Engineering and Applied Scienceen_US
dc.contributor.ethics-approvalNot Applicableen_US
dc.contributor.external-examinern/aen_US
dc.contributor.graduate-coordinatorGibson, Men_US
dc.contributor.manuscriptsNot Applicableen_US
dc.contributor.thesis-readerSu-Ling Brooksen_US
dc.contributor.thesis-readerAmyl Ghanemen_US
dc.contributor.thesis-supervisorTom Gill, Allan Paulsonen_US
dc.date.accessioned2014-08-26T12:37:17Z
dc.date.available2014-08-26T12:37:17Z
dc.date.defence2014-08-14
dc.date.issued2014-08-26
dc.description.abstractBioactive low molecular weight protein hydrolysates need to be protected, transported to the targeted absorption site, and released in a controlled manner to optimize their effectiveness during oral administration. The focus of this research was to develop a chitosan-coated liposomal oral delivery system with milk fat globule membrane (MFGM) phospholipids for antidiabetic Atlantic salmon protein hydrolysates (SPH). The size, zeta potential, entrapment efficiency, stability during freeze-drying and freeze thawing, and long-term storage abilities were investigated as a function of phospholipid concentration and chitosan coating concentration. Chitosan coating greatly improved the stability of MFGM liposomes. The maximum encapsulation efficiency (71.3%) and physical stability were achieved with 10% MFGM and 0.4% chitosan. Chitosan coating significantly prolongs the release of SPH in simulated biological fluids. In conclusion, liposomes with “optimal” chitosan-coating-concentration show great promise as a potential new delivery system for protein hydrolysates. However, the bioactivity of encapsulated SPH need to be tested.en_US
dc.identifier.urihttp://hdl.handle.net/10222/54045
dc.language.isoenen_US
dc.subjectEncapsulationen_US
dc.subjectLiposomeen_US
dc.subjectChitosanen_US
dc.subjectProtein hydrolysatesen_US
dc.titleENCAPSULATION OF BIOACTIVE SALMON PROTEIN HYDROLYSATES WITH CHITOSAN-COATED LIPOSOMESen_US

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