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The Development of a 3D Piezoelectric Active Microtissue Model for Airway Smooth Muscle

dc.contributor.authorWalker, Matthew
dc.contributor.copyright-releaseNot Applicableen_US
dc.contributor.degreeMaster of Applied Scienceen_US
dc.contributor.departmentDepartment of Biomedical Engineeringen_US
dc.contributor.ethics-approvalNot Applicableen_US
dc.contributor.external-examinerRob Adamsonen_US
dc.contributor.graduate-coordinatorSarah Wellsen_US
dc.contributor.manuscriptsNot Applicableen_US
dc.contributor.thesis-readerJeremy Brownen_US
dc.contributor.thesis-readerPaul Gratzeren_US
dc.contributor.thesis-supervisorGeoff Maksymen_US
dc.date.accessioned2013-04-30T17:52:14Z
dc.date.available2013-04-30T17:52:14Z
dc.date.defence2013-04-08
dc.date.issued2013-04-30
dc.description.abstractAlthough asthma is primarily thought to be an inflammatory disease of the airways, it has recently been hypothesized that the altered mechanical environment of an asthmatic airway may contribute to the development of the disease through changes in cellular phenotype. In regards to this hypothesis, the effects of stretch on airway smooth muscle (ASM) have previously been investigated using 2D cell culture. However, over the last few years there has been an increasing appreciation to the importance of the role of the 3D extracellular matrix in the regulation of cellular response. For this reason, the work presented in this thesis covers the development of a device capable of high-throughput investigations into the effects of acute or chronic, uniaxial, oscillatory mechanical strain on an array of miniature, 3D, multi-cell, tissue-engineered constructs.en_US
dc.identifier.urihttp://hdl.handle.net/10222/21862
dc.language.isoenen_US
dc.subjectMicrotisseen_US
dc.subjectPiezoelectricen_US
dc.subject3D Cell Cultureen_US
dc.subjectAirway Smooth Muscleen_US
dc.subjectStretchen_US
dc.subjectAsthmaen_US
dc.subjectMechanobiologyen_US
dc.titleThe Development of a 3D Piezoelectric Active Microtissue Model for Airway Smooth Muscleen_US

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