Antimicrobial Activities of Jadomycin B and Structurally Related Analogues
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Jakeman, David L.
Bandi, Srinivasulu
Graham, Cathy L.
Reid, Taryn R.
Wentzell, Jason R.
Douglas, Susan E.
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Abstract
Natural products are leads for new antibiotics as a result of their structural complexity and
diversity. We have isolated a series of structurally related polyketide-derived natural products
from Streptomyces venezuelae ISP5230. The most active of these jadomycin analogues showed good
activity against a variety of staphylococci, including methicillin-resistant Staphylococcus
aureus.
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Jakeman, David L., Srinivasulu Bandi, Cathy L. Graham, Taryn R. Reid, et al. 2009. "Antimicrobial Activities of Jadomycin B and Structurally Related Analogues." Antimicrobial Agents and Chemotherapy 53(3): 1245-1247.