An Investigation of the Auditory Mismatch Negativity Elicited by Complex Stimuli in Early-Phase Psychosis

Abstract

Introduction: Reduction of mismatch-negativity (MMN) has been well characterized in individuals with chronic schizophrenia. However, there is a lack of MMN research in early-phase psychosis (EPP). We investigated MMN elicited by complex stimuli in EPP, hypothesizing that the complexity of MMN stimuli is better suited for identifying deficits in individuals with EPP. Methods: Thirteen EPP patients and 33 controls were included in the study. Demographic, symptom severity, and functional data were collected. MMN was measured with a novelty and emotional paradigm. Results: The groups did not differ in MMN amplitude. We observed a shorter latency for the EPP group and correlations between MMN, negative symptoms, and overall functioning within the novelty paradigm. Discussion: Our hypothesis was not supported as we observed no between-group differences. Our results support that good social and occupational functioning is associated with better sensory processing and that shorter MMN latencies is associated with positive psychotic symptoms.