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10 Days of Darkness Does Not Restore Neural or Visual Plasticity in Adult Cats

dc.contributor.authorHolman, Kaitlyn
dc.contributor.copyright-releaseNot Applicableen_US
dc.contributor.degreeMaster of Scienceen_US
dc.contributor.departmentDepartment of Medical Neuroscienceen_US
dc.contributor.ethics-approvalReceiveden_US
dc.contributor.external-examinerIan Weaveren_US
dc.contributor.graduate-coordinatorKazue Sembaen_US
dc.contributor.manuscriptsNot Applicableen_US
dc.contributor.thesis-readerKazue Sembaen_US
dc.contributor.thesis-readerDonald Mitchellen_US
dc.contributor.thesis-supervisorKevin Duffyen_US
dc.contributor.thesis-supervisorWilliam Baldridge
dc.date.accessioned2014-12-11T18:05:27Z
dc.date.available2014-12-11T18:05:27Z
dc.date.defence2014-11-28
dc.date.issued2014-12-11
dc.description.abstractRecently it was demonstrated that 10-days of darkness could restore visual plasticity and promote fast and complete recovery from amblyopia in juvenile kittens (Duffy and Mitchell, 2013). To test whether 10-days of darkness could restore plasticity and promote recovery from amblyopia in adult cats (≥1year), two sets of studies were conducted. First, the effect of darkness on promoting recovery from monocular deprivation was tested behaviourally by examining the visual acuity of amblyopic adult cats placed in darkness, and examined histologically by measurement of soma size and neurofilament-H (NF-H) label density in the dorsal lateral geniculate nucleus (dLGN). Second, the capacity of darkness to induce plasticity in normal adult cats was tested through examining the effect of a subsequent period of monocular deprivation on visual acuity and on soma size and NF-H label density in the dLGN. In all conditions examined, darkness was wholly unable to promote visual or anatomical plasticity.en_US
dc.identifier.urihttp://hdl.handle.net/10222/55998
dc.language.isoenen_US
dc.subjectNeuroscienceen_US
dc.subjectPlasticityen_US
dc.subjectDevelopmenten_US
dc.subjectNeurofilamenten_US
dc.subjectAmblyopiaen_US
dc.subjectLateral Geniculate Nucleusen_US
dc.subjectCaten_US
dc.subjectCritical Periodsen_US
dc.subjectVisionen_US
dc.title10 Days of Darkness Does Not Restore Neural or Visual Plasticity in Adult Catsen_US
dc.typeThesisen_US

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