THE IMPACT OF OCCLUSION THERAPY AND PREDICTORS ON AMBLYOPIA DOSE-RESPONSE RELATIONSHIP AND SUCCESS OUTCOMES

Abstract

Amblyopia is a decrease in visual acuity caused by abnormal binocular interaction or pattern vision deprivation in one or both eye(s) with no organic abnormalities which is reversible by therapeutic measures. Current research on amblyopia treatment lacks dose standardization, dose-response rate estimates, and age limits. One common treatment is occlusion therapy. This study aimed to determine the success outcomes of occlusion therapy, dose-response rate of visual acuity to occlusion therapy, and explore predictors for occlusion therapy success and dose-response rates. Results showed 90.3% treatment success and dose-response rate of 224hours/0.1 logMAR increase. To reach outcome visual acuity, a total dose of 1344 hours (FTO) and 504 hours (PTO) was required. Classification of amblyopia, age, visual acuity chart used, initial distance vision in the amblyopic eye, and treatment dose predicted dose-response rate. Significant variables for treatment success included initial distance vision in the amblyopic eye and initial interocular visual difference.