Repository logo
 

A Sex-dependent Response to dl-PHPB in an Amyotrophic Lateral Sclerosis Disease Mouse Model

dc.contributor.authorMacKenzie, Uduak
dc.contributor.copyright-releaseNot Applicableen_US
dc.contributor.degreeMaster of Scienceen_US
dc.contributor.departmentDepartment of Medical Neuroscienceen_US
dc.contributor.ethics-approvalReceiveden_US
dc.contributor.external-examinerDr. Turgay Akayen_US
dc.contributor.graduate-coordinatorDr. Kazue Sembaen_US
dc.contributor.manuscriptsNot Applicableen_US
dc.contributor.thesis-readerDr. Victor Rafuseen_US
dc.contributor.thesis-supervisorDr. Ying Zhangen_US
dc.date.accessioned2021-04-28T12:17:42Z
dc.date.available2021-04-28T12:17:42Z
dc.date.defence2021-04-19
dc.date.issued2021-04-28T12:17:42Z
dc.description.abstractAmyotrophic Lateral Sclerosis is a fatal neurodegenerative disease affecting upper and lower motor neurons resulting in their death. There are currently only two FDA approved drugs for its treatment, and both offer mild effects on the disease. Hence the need for a continued search for a better and more effective treatment. dl-Potassium 2-(1-Hydroxypentyl)-benzoate (dl-PHPB) is a novel drug for the treatment of cerebral ischemia and has shown potential neuroprotective, anti-oxidative and anti-apoptotic benefits in several neurodegenerative diseases. In this study, the effects of dl-PHPB treatment are investigated in SOD1G93A mice, an animal model for ALS disease. Our results show that dl-PHPB has neuroprotective effects that are able to delay disease onset and progression, and also improve locomotor function particularly in female animals. Further investigation will be needed to confirm dl-PHPB as a drug candidate for the treatment of ALS and its effects on different gender groups.en_US
dc.identifier.urihttp://hdl.handle.net/10222/80431
dc.language.isoen_USen_US
dc.subjectAmyotrophic Lateral Sclerosisen_US
dc.subjectdl-PHPBen_US
dc.subjectFemaleen_US
dc.subjectGenderen_US
dc.subjectALS treatmenten_US
dc.subjectDrug treatmenten_US
dc.titleA Sex-dependent Response to dl-PHPB in an Amyotrophic Lateral Sclerosis Disease Mouse Modelen_US
dc.typeThesisen_US

Files

Original bundle

Now showing 1 - 1 of 1
Loading...
Thumbnail Image
Name:
UduakMacKenzie2021.pdf
Size:
2.17 MB
Format:
Adobe Portable Document Format
Description:
Masters Thesis document (main article)

License bundle

Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description: