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Cardioprotective effect of Na+/Ca2+ exchange inhibition in cardioplegic arrest by SEA0400

dc.contributor.authorEgar, Jeanne
dc.contributor.copyright-releaseNot Applicableen_US
dc.contributor.degreeMaster of Scienceen_US
dc.contributor.departmentDepartment of Physiology & Biophysicsen_US
dc.contributor.ethics-approvalNot Applicableen_US
dc.contributor.external-examinerDr. Camille Hancock Friesenen_US
dc.contributor.graduate-coordinatorDr. Robert Roseen_US
dc.contributor.manuscriptsNot Applicableen_US
dc.contributor.thesis-readerDr. Jean-Francois Legare, Dr. Robert Roseen_US
dc.contributor.thesis-supervisorDr. Stacy O'Blenesen_US
dc.date.accessioned2013-08-20T19:25:46Z
dc.date.available2013-08-20T19:25:46Z
dc.date.defence2013-08-06
dc.date.issued2013-08-20
dc.description.abstractThis study investigated the effects of SEA0400, a Na+/Ca2+ exchange inhibitor, in cardioplegia on rat myocyte contractile function. SEA0400 significantly reduced the accumulation of diastolic Ca2+ throughout cardioplegic arrest compared to ischemic control and cardioplegia. Cells treated with SEA0400 during cardioplegic arrest showed significantly larger Ca2+ transient amplitudes and contractions throughout reperfusion compared to cells treated with cardiopelgia alone. Intracellular Ca2+ stores were similar in both cardioplegic groups at baseline and during reperfusion. Together these results suggest that SEA0400 has beneficial effects at protecting ventricular myocytes during cardioplegic arrest and that SEA0400 in cardioplegia may affect myofilament Ca2+ sensitivity.en_US
dc.identifier.urihttp://hdl.handle.net/10222/35431
dc.language.isoenen_US
dc.subjectCardioplegia, SEA0400, sodium calcium exchange blocker, ischemic arresten_US
dc.titleCardioprotective effect of Na+/Ca2+ exchange inhibition in cardioplegic arrest by SEA0400en_US

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