Repository logo
 

Comparisons Between Parkinson’s Disease Patients and At-Risk Individuals: Can Olfactory Deficits, Cognitive Measures, and Brain Network Connectivity Serve as Preclinical Markers?

dc.contributor.authorPimer, Laura
dc.contributor.copyright-releaseNot Applicableen_US
dc.contributor.degreeMaster of Scienceen_US
dc.contributor.departmentDepartment of Psychiatry Researchen_US
dc.contributor.ethics-approvalReceiveden_US
dc.contributor.external-examinern/aen_US
dc.contributor.graduate-coordinatorDr. Sherry Stewarten_US
dc.contributor.manuscriptsNot Applicableen_US
dc.contributor.thesis-readerDr. Javeria Hashmien_US
dc.contributor.thesis-readerDr. Beverly Butleren_US
dc.contributor.thesis-readerDr. Tim Bardouilleen_US
dc.contributor.thesis-supervisorDr. Kimberley Gooden_US
dc.date.accessioned2021-08-23T14:46:19Z
dc.date.available2021-08-23T14:46:19Z
dc.date.defence2021-07-22
dc.date.issued2021-08-23T14:46:19Z
dc.description.abstractAlthough olfactory deficits (hyposmia) are potential early markers of Parkinson’s disease (PD), they are not specific to PD. This study examined whether cognitive deficits and/or aberrant resting-state functional connectivity (FC) within the default mode network (DMN) may serve as additional early markers of PD for at-risk individuals. PD patients, healthy controls, and an at-risk group (AR) including hyposmic first-degree relatives of PD patients and unrelated hyposmic individuals were compared on a neuropsychological test battery and on DMN FC. The PD and AR groups showed significant verbal working memory deficits compared to controls. PD patients also exhibited processing speed deficits. AR individuals showed increased DMN FC between the anterior medial prefrontal cortex and the right middle temporal gyrus compared to controls and PD patients. Working memory deficits and increased DMN FC in addition to hyposmia could indicate the progression towards PD. Future research is needed to determine the findings’ clinical applicability.en_US
dc.identifier.urihttp://hdl.handle.net/10222/80710
dc.language.isoenen_US
dc.subjectParkinson's diseaseen_US
dc.subjecthyposmiaen_US
dc.subjectresting-state functional connectivityen_US
dc.subjectcognitive functionen_US
dc.subjectdefault mode networken_US
dc.titleComparisons Between Parkinson’s Disease Patients and At-Risk Individuals: Can Olfactory Deficits, Cognitive Measures, and Brain Network Connectivity Serve as Preclinical Markers?en_US

Files

Original bundle

Now showing 1 - 1 of 1
Loading...
Thumbnail Image
Name:
LauraPimer2021.pdf
Size:
3.81 MB
Format:
Adobe Portable Document Format
Description:

License bundle

Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description: