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HUMAN MAST CELL RESPONSES TO RESPIRATORY SYNCYTIAL VIRUS

dc.contributor.authorAl-Afif, Ayham
dc.contributor.copyright-releaseNot Applicableen_US
dc.contributor.degreeMaster of Scienceen_US
dc.contributor.departmentDepartment of Microbiology & Immunologyen_US
dc.contributor.ethics-approvalNot Applicableen_US
dc.contributor.external-examinerDr. Patrick Leeen_US
dc.contributor.graduate-coordinatorDr. Roy Duncanen_US
dc.contributor.manuscriptsNot Applicableen_US
dc.contributor.thesis-readerDr. Craig McCormick, Dr. Robert Liwskien_US
dc.contributor.thesis-supervisorDr. Jean Marshall (primary supervisor), Dr. Robert Anderson (co-supervisor)en_US
dc.date.accessioned2012-11-20T15:46:27Z
dc.date.available2012-11-20T15:46:27Z
dc.date.defence2011-07-08
dc.date.issued2012-11-20
dc.description.abstractMast cells reside at tissue sites closely interfacing the environment and play a role in host defense against pathogens. Mast cell responses to respiratory syncytial virus (RSV), a major cause of severe respiratory tract infections and subsequent bronchiolitis, are not fully elucidated. Human cord blood-derived mast cells (CBMCs) and the HMC-1 mast cell line supported low levels of RSV antigen expression as compared with airway epithelial cells. RSV inoculated mast cells up-regulated the expression of several chemokines such as CCL4, CCL5 and CXCL10, as well as type I and III interferons. Type I interferon receptor blockade on RSV-inoculated HMC-1 cells had no effect on chemokine production or viral antigen expression. These data show that mast cells respond to RSV by expressing various cytokines and chemokines that may enhance inflammation and effector cell recruitment during RSV disease.en_US
dc.identifier.urihttp://hdl.handle.net/10222/15709
dc.language.isoenen_US
dc.subjectVirus, Inflammation, Immuology, Microbiologyen_US
dc.titleHUMAN MAST CELL RESPONSES TO RESPIRATORY SYNCYTIAL VIRUSen_US

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