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Chitosan-Polyphosphate Complexation for Fabrication of Advanced Functional Biomaterials

dc.contributor.authorFanaee, Sajjad
dc.contributor.copyright-releaseYes
dc.contributor.degreeDoctor of Philosophy
dc.contributor.departmentSchool of Biomedical Engineering
dc.contributor.ethics-approvalNot Applicable
dc.contributor.external-examinerDr. Marc Lavertu
dc.contributor.manuscriptsYes
dc.contributor.thesis-readerDr. Paul Gratzer
dc.contributor.thesis-readerDr. Michael Freund
dc.contributor.thesis-readerDr. Arash Momeni
dc.contributor.thesis-supervisorDr. Mark Filiaggi
dc.contributor.thesis-supervisorDr. Vahid Adibnia
dc.date.accessioned2024-11-21T14:13:28Z
dc.date.available2024-11-21T14:13:28Z
dc.date.defence2024-10-22
dc.date.issued2024-11-20
dc.description.abstractThis thesis investigates the complexation between Chitosan (CS) and Polyphosphate (PP) for advanced biomedical applications, including drug delivery and hemostasis. It highlights the previously overlooked effect of PP chain length, along with the influence of polyelectrolyte (PE) mixing ratio and salt addition on CS-PP interactions. A phase diagram revealed that salt moderated PE interactions, though coacervate formation was not achieved under the studied conditions. Insights from these studies informed the design of CS-PP macrobeads for antibiotic delivery, optimized by enhancing PP diffusion into CS droplets and adjusting salt levels. Additionally, superabsorbent hemostatic sponges were developed by chemically modifying CS with carboxyl groups to regulate PP release as a therapeutic agent for improved clotting. These sponges demonstrated enhanced blood absorption, controlled PP release, and significantly reduced clotting time. This work provides a deeper understanding of the CS-PP system, emphasizing its biomedical potential while addressing challenges in optimizing performance and functionality.
dc.identifier.urihttps://hdl.handle.net/10222/84699
dc.language.isoen
dc.subjectPolyelectrolyte complexation
dc.subjectChitosan
dc.subjectPolyphosphate
dc.subjectHemostasis
dc.subjectBleeding
dc.subjectControlled release
dc.titleChitosan-Polyphosphate Complexation for Fabrication of Advanced Functional Biomaterials

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