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Early exposure to parental bipolar illness and risk of mood disorder

dc.contributor.authorDoucette, Sarah Margaret
dc.contributor.copyright-releaseNot Applicableen_US
dc.contributor.degreeMaster of Scienceen_US
dc.contributor.departmentDepartment of Community Health & Epidemiologyen_US
dc.contributor.ethics-approvalNot Applicableen_US
dc.contributor.external-examinern/aen_US
dc.contributor.graduate-coordinatorDr. Kathleen MacPhersonen_US
dc.contributor.manuscriptsNoen_US
dc.contributor.thesis-readerDr. Kathleen MacPhersonen_US
dc.contributor.thesis-readerDr. Gordon Flowerdewen_US
dc.contributor.thesis-supervisorDr. Adrian Levy, Dr. Anne Duffyen_US
dc.date.accessioned2013-08-27T16:08:04Z
dc.date.available2013-08-27T16:08:04Z
dc.date.defence2013-08-19
dc.date.issued2013-08-27
dc.description.abstractThe objective of this thesis was to determine the association between exposure to parental BD during childhood and risk of mood disorder. Offspring of one parent with BD completed annual clinical assessments as part of a 16-year prospective cohort study. Clinical data in the parents from Ottawa and Halifax were mapped onto the first decade of their offspring’s life to estimate the timing, duration and severity of exposure to their illness. The duration of parental BD was associated with a 2 to 2.5 fold increased risk of any psychopathology (HR: 1.9, 95%CI: 1.0-4.0), and unipolar depression (HR: 2.6, 95%CI: 0.9-7.5), and a 7 fold increased risk of substance use disorders (HR: 7.1, 95%CI: 1.8-37.0). A longer duration of exposure to parental BD may be an important indicator of mood and non-mood psychopathology risk in offspring. This has implications for early intervention and preventive efforts in high-risk youth.en_US
dc.identifier.urihttp://hdl.handle.net/10222/36265
dc.language.isoenen_US
dc.subjectMood disordersen_US
dc.subjectEarly environmenten_US
dc.subjectBipolar disorder, mood disorders, high-risk offspring, early adversity, early environmenten_US
dc.subjectHigh-risk offspringen_US
dc.titleEarly exposure to parental bipolar illness and risk of mood disorderen_US
dc.typeThesisen_US

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