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Introducing the tellurophene-appended BODIPY: PDT agent with mass cytometry tracking capabilities

dc.contributor.authorJacob W. Campbell
dc.contributor.authorMatthew T. Tung
dc.contributor.authorRoberto M. Diaz-Rodriguez
dc.contributor.authorKatherine N. Robertson
dc.contributor.authorAndrew A. Beharry
dc.contributor.authorAlison Thompson
dc.date.accessioned2025-07-28T17:10:38Z
dc.date.available2025-07-28T17:10:38Z
dc.date.issued2021-11-22
dc.description.abstractThe synthesis and characterization of the first BODIPY appended to the five-membered heterocylic tellurophene [Te] moiety is reported. By incorporating tellurophene at the meso position, the tellurophene-appended boron-dipyrromethene dye (BODIPY) acts as a multimodal agent, becoming a potent photosensitizer with a mass cytometry tag. To synthesize the compound, we developed a method to enable late-stage Suzuki–Miyaura coupling by preparing and isolating tellurophene-2-BPin in a one-step procedure from the parent tellurophene. Coupling to a meso-substituted BODIPY functionalized with a pendant aryl bromide provides the desired tellurophene-appended BODIPY. This compound demonstrated a singlet oxygen quantum yield of 0.26 ± 0.01 and produced a light dose-dependent cytotoxicity with nanomolar IC50 values against 2D cultured HeLa cells and high efficacy against 3D cultured HeLa tumor spheroids, proving to be a strong photosensitizer. The presence of the tellurophene moiety could be detected using mass cytometry, thus showcasing the ability of a tellurophene-appended BODIPY as a novel photodynamic-therapy–mass-cytometry theranostic agent.
dc.identifier.citationPublished Version: ACS Med. Chem. Lett. 2021, 12, 12, 1925–1931 https://doi.org/10.1021/acsmedchemlett.1c00492
dc.identifier.urihttps://hdl.handle.net/10222/85238
dc.publisherAmerican Chemical Society
dc.relation.ispartofACS Medicinal Chemistry Letters
dc.titleIntroducing the tellurophene-appended BODIPY: PDT agent with mass cytometry tracking capabilities
dc.typeArticle

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