Introducing the tellurophene-appended BODIPY: PDT agent with mass cytometry tracking capabilities
dc.contributor.author | Jacob W. Campbell | |
dc.contributor.author | Matthew T. Tung | |
dc.contributor.author | Roberto M. Diaz-Rodriguez | |
dc.contributor.author | Katherine N. Robertson | |
dc.contributor.author | Andrew A. Beharry | |
dc.contributor.author | Alison Thompson | |
dc.date.accessioned | 2025-07-28T17:10:38Z | |
dc.date.available | 2025-07-28T17:10:38Z | |
dc.date.issued | 2021-11-22 | |
dc.description.abstract | The synthesis and characterization of the first BODIPY appended to the five-membered heterocylic tellurophene [Te] moiety is reported. By incorporating tellurophene at the meso position, the tellurophene-appended boron-dipyrromethene dye (BODIPY) acts as a multimodal agent, becoming a potent photosensitizer with a mass cytometry tag. To synthesize the compound, we developed a method to enable late-stage Suzuki–Miyaura coupling by preparing and isolating tellurophene-2-BPin in a one-step procedure from the parent tellurophene. Coupling to a meso-substituted BODIPY functionalized with a pendant aryl bromide provides the desired tellurophene-appended BODIPY. This compound demonstrated a singlet oxygen quantum yield of 0.26 ± 0.01 and produced a light dose-dependent cytotoxicity with nanomolar IC50 values against 2D cultured HeLa cells and high efficacy against 3D cultured HeLa tumor spheroids, proving to be a strong photosensitizer. The presence of the tellurophene moiety could be detected using mass cytometry, thus showcasing the ability of a tellurophene-appended BODIPY as a novel photodynamic-therapy–mass-cytometry theranostic agent. | |
dc.identifier.citation | Published Version: ACS Med. Chem. Lett. 2021, 12, 12, 1925–1931 https://doi.org/10.1021/acsmedchemlett.1c00492 | |
dc.identifier.uri | https://hdl.handle.net/10222/85238 | |
dc.publisher | American Chemical Society | |
dc.relation.ispartof | ACS Medicinal Chemistry Letters | |
dc.title | Introducing the tellurophene-appended BODIPY: PDT agent with mass cytometry tracking capabilities | |
dc.type | Article |