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Physiological Remodelling of Mitral Valve Chordae Tendineae In The Maternal Bovine Heart

dc.contributor.authorScott, Brandon
dc.contributor.copyright-releaseNot Applicableen_US
dc.contributor.degreeMaster of Applied Scienceen_US
dc.contributor.departmentDepartment of Biomedical Engineeringen_US
dc.contributor.ethics-approvalNot Applicableen_US
dc.contributor.external-examinerN/Aen_US
dc.contributor.graduate-coordinatorDr. Janie Wilsonen_US
dc.contributor.manuscriptsNot Applicableen_US
dc.contributor.thesis-readerDr. Mike Leeen_US
dc.contributor.thesis-readerDr. Samuel Veresen_US
dc.contributor.thesis-readerDr. John Framptonen_US
dc.contributor.thesis-supervisorDr. Sarah Wellsen_US
dc.date.accessioned2016-08-11T17:29:16Z
dc.date.available2016-08-11T17:29:16Z
dc.date.defence2016-07-22
dc.date.issued2016-08-11T17:29:16Z
dc.description.abstractPregnancy is a cardiac volume-overload state that triggers heart valve remodelling. The bovine mitral valve anterior leaflet increases in area by ~35%, with a striking ~22% increase in the number of chordae tendineae attachments. It is hypothesized that the maternal increase in chordae number results from the splitting of existing tendons. Chordae from never-pregnant heifers and pregnant cows were harvested from a local abattoir. Differential scanning calorimetry was performed to assess collagen thermal stability, and histological sections were stained with Picrosirius Red and Movat Pentachrome, and immunostained for α-SMA and periostin. Collagen thermal stability, collagen crimp, the quantity of activated valvular interstitial cells, and periostin expression were unchanged between pregnancy groups. However, chordae bifurcations showed evidence of enhanced extracellular matrix remodelling compared to the surrounding tissue. This work suggests that chordae splitting may occur in both heifers and pregnant cows as a fundamental, routine tissue turnover mechanism.en_US
dc.identifier.urihttp://hdl.handle.net/10222/72057
dc.language.isoenen_US
dc.subjectRemodellingen_US
dc.subjectCardiovascularen_US
dc.subjectPregnancyen_US
dc.subjectDifferential Scanning Calorimetryen_US
dc.subjectCollagenen_US
dc.subjectValvular Interstitial Cellen_US
dc.subjectMitral Valveen_US
dc.subjectChordae Tendineaeen_US
dc.subjectCows - Physiology
dc.titlePhysiological Remodelling of Mitral Valve Chordae Tendineae In The Maternal Bovine Hearten_US

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