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AGE-RELATED WEIGHT LOSS IN THE 5XFAD MOUSE MODEL OF ALZHEIMER’S DISEASE: A BEHAVIOURAL AND HORMONAL ANALYSIS

dc.contributor.authorGendron, William
dc.contributor.copyright-releaseNot Applicableen_US
dc.contributor.degreeMaster of Scienceen_US
dc.contributor.departmentNeuroscienceen_US
dc.contributor.ethics-approvalReceiveden_US
dc.contributor.external-examinern/aen_US
dc.contributor.graduate-coordinatorGail Eskesen_US
dc.contributor.manuscriptsNot Applicableen_US
dc.contributor.thesis-readerTara Perroten_US
dc.contributor.thesis-readerYounes Aninien_US
dc.contributor.thesis-supervisorRichard Brownen_US
dc.date.accessioned2015-08-19T13:07:43Z
dc.date.available2015-08-19T13:07:43Z
dc.date.defence2015-07-07
dc.date.issued2015
dc.description.abstractThe 5xFAD mice exhibit weight loss at 9 months of age. We investigated age-related changes in body weight, feeding behaviour, activity levels, feeding-related hormones, and proteins regulating adipogenesis and thermogenesis in female 5xFAD mice and their WT controls. The 5xFAD mice were hypoactive in climbing and rearing (p<0.05), and were frequently still (p<0.05). Differences in food intake and body weight occurred at 9 and 12 months of age, where WT ate and weighed more (p<0.05). The 5xFAD mice had less white adipose tissue (WAT); p<0.05). Expression of leptin mRNA, UCP-2, UCP-1, and HSL were measured in WAT and did not differ between genotypes (p<0.05). Transgenic mice expressed more UCP-1 (p<0.05). At 9 and 12 months of age, the 5xFAD mice ate less, had a lower body weight and were hypoactive. At 12 months of age the 5xFAD mice had less body fat and expressed less leptin, UCP-2, and HSL mRNA.en_US
dc.identifier.urihttp://hdl.handle.net/10222/60526
dc.language.isoenen_US
dc.subjectAlzheimer's diseaseen_US
dc.subjectAgeingen_US
dc.subjectMetabolismen_US
dc.titleAGE-RELATED WEIGHT LOSS IN THE 5XFAD MOUSE MODEL OF ALZHEIMER’S DISEASE: A BEHAVIOURAL AND HORMONAL ANALYSISen_US
dc.typeThesisen_US

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