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EXPLORING THE SUSCEPTIBILITY TO CARDIAC ARRHYTHMIAS AND UNDERLYING MECHANISMS IN PULMONARY ARTERIAL HYPERTENSION

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dc.contributor.authorEl-Rabahi, Tony
dc.contributor.copyright-releaseNot Applicableen_US
dc.contributor.degreeMaster of Scienceen_US
dc.contributor.departmentDepartment of Physiology & Biophysicsen_US
dc.contributor.ethics-approvalReceiveden_US
dc.contributor.external-examinern/aen_US
dc.contributor.graduate-coordinatorDr. Y. El-Hianien_US
dc.contributor.manuscriptsNot Applicableen_US
dc.contributor.thesis-readerDr. T. Alexander Quinnen_US
dc.contributor.thesis-readerDr. P. Kienesbergeren_US
dc.contributor.thesis-readerDr. J Sappen_US
dc.contributor.thesis-supervisorDr. K.R Chaudharyen_US
dc.date.accessioned2023-07-26T18:04:32Z
dc.date.available2023-07-26T18:04:32Z
dc.date.defence2023-06-14
dc.date.issued2023-07-25
dc.description.abstractBackground: Pulmonary arterial hypertension (PAH) is a progressive incurable disease with unclear etiology. Primary cause of death in PAH patients is right (-sided) heart failure, occurring as a direct consequence of increased right ventricular (RV) afterload. Importantly, around 25% of these deaths have been linked to cardiac arrhythmias. However, mechanisms underlying arrhythmia susceptibility in patients with elevated pulmonary arterial and RV pressure remains unclear Conclusions: PAH in Fischer rats treated with MCT was associated with electrical remodeling and reduced vascular density. These changes in RV may contribute to increased susceptibility to arrhythmias and sudden death in PAH.en_US
dc.identifier.urihttp://hdl.handle.net/10222/82728
dc.language.isoenen_US
dc.subjectCardiac Arrhythmiasen_US
dc.subjectPulmonary Hypertensionen_US
dc.subjectPulmonary Arterial Hypertensionen_US
dc.subjectElectrical Remodelingen_US
dc.titleEXPLORING THE SUSCEPTIBILITY TO CARDIAC ARRHYTHMIAS AND UNDERLYING MECHANISMS IN PULMONARY ARTERIAL HYPERTENSIONen_US
dc.typeThesisen_US

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