The Development of V3 interneurons in the mouse spinal cord
| dc.contributor.author | Blacklaws, Jake | |
| dc.contributor.copyright-release | Not Applicable | en_US |
| dc.contributor.degree | Master of Science | en_US |
| dc.contributor.department | Department of Medical Neuroscience | en_US |
| dc.contributor.ethics-approval | Not Applicable | en_US |
| dc.contributor.external-examiner | Jim Fawcett | en_US |
| dc.contributor.graduate-coordinator | Kazue Semba | en_US |
| dc.contributor.manuscripts | Not Applicable | en_US |
| dc.contributor.thesis-reader | Kazue Semba | en_US |
| dc.contributor.thesis-reader | Bill Baldridge | en_US |
| dc.contributor.thesis-supervisor | Ying Zhang | en_US |
| dc.date.accessioned | 2013-08-07T16:34:32Z | |
| dc.date.available | 2013-08-07T16:34:32Z | |
| dc.date.defence | 2013-07-26 | |
| dc.date.issued | 2013-08-07 | |
| dc.description.abstract | V3 interneurons in the spinal cord are a group of excitatory commissural interneurons that play an important role in producing balanced and stable gaits in animals. We discovered that Sim1-expressing V3 interneurons arise from the ventral-most progenitor domain in the developing neural tube and migrate in a dorso-lateral trajectory to settle into three distinct subpopulations. The most ventral subpopulation projects axons in both an rostral and caudal direction, while the intermediate and dorsal subpopulations are mostly rostrally-projecting. The role of Sim1 as a transcription factor was shown to play a role both in the proper migration and axon projection of V3 interneurons. | en_US |
| dc.identifier.uri | http://hdl.handle.net/10222/34629 | |
| dc.language.iso | en | en_US |
| dc.subject | V3 interneurons | en_US |
| dc.title | The Development of V3 interneurons in the mouse spinal cord | en_US |