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The Association between Prior Seasonal Influenza Vaccination and Subsequent Seasonal Influenza Vaccine Effectiveness in Canada

dc.contributor.authorNichols, Michaela
dc.contributor.copyright-releaseNoen_US
dc.contributor.degreeMaster of Scienceen_US
dc.contributor.departmentDepartment of Community Health & Epidemiologyen_US
dc.contributor.ethics-approvalReceiveden_US
dc.contributor.external-examinerN/Aen_US
dc.contributor.graduate-coordinatorDr. Kathleen MacPhersonen_US
dc.contributor.manuscriptsNoen_US
dc.contributor.thesis-readerDr. Kathleen MacPhersonen_US
dc.contributor.thesis-readerDr. Todd Hatchetteen_US
dc.contributor.thesis-readerDr. Bruce Smithen_US
dc.contributor.thesis-readerDr. Shelly McNeilen_US
dc.contributor.thesis-supervisorDr. Kathleen MacPhersonen_US
dc.contributor.thesis-supervisorDr. Shelly McNeilen_US
dc.date.accessioned2016-08-29T12:42:48Z
dc.date.available2016-08-29T12:42:48Z
dc.date.defence2016-08-10
dc.date.issued2016-08-29T12:42:48Z
dc.description.abstractInfluenza is a major burden to the health of thousands of Canadians every year. Recent observational studies have suggested that prior influenza vaccination could impact subsequent influenza vaccine effectiveness (VE) under some circumstances. This study investigates the association between prior influenza vaccination and subsequent seasonal influenza VE in three influenza seasons in Canada (2011-2014). Using a test-negative control design, the Canadian Immunization Research Network’s (CIRN) Serious Outcomes Surveillance (SOS) network prospectively identified cases and matched controls from each study season using active influenza surveillance in hospitals. Overall, results of conditional logistic regression analyses provide some evidence for an association between prior influenza vaccination and subsequent influenza VE in Canada. This association varied depending on the strain and season under observation. Future prospective studies to examine this association and to explore contributing biological and immunological mechanisms are critical to inform influenza immunization policy in Canada.en_US
dc.identifier.urihttp://hdl.handle.net/10222/72123
dc.language.isoenen_US
dc.subjectInfluenzaen_US
dc.subjectVaccinologyen_US
dc.subjectVaccine Effectivenessen_US
dc.subjectObservational Studyen_US
dc.subjectVaccines
dc.titleThe Association between Prior Seasonal Influenza Vaccination and Subsequent Seasonal Influenza Vaccine Effectiveness in Canadaen_US

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