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CHARACTERIZATION AND DEVELOPMENT OF THE M2 MELANOPSIN RETINAL GANGLION CELL IN THE CLM-1 TRANSGENIC MOUSE RETINA

dc.contributor.authorHusain, Sahira Fathima
dc.contributor.copyright-releaseNot Applicableen_US
dc.contributor.degreeMaster of Scienceen_US
dc.contributor.departmentDepartment of Clinical Vision Scienceen_US
dc.contributor.ethics-approvalReceiveden_US
dc.contributor.external-examinerKevin Duffyen_US
dc.contributor.graduate-coordinatorKaren McMainen_US
dc.contributor.manuscriptsNot Applicableen_US
dc.contributor.thesis-readerBalwantray Chauhanen_US
dc.contributor.thesis-readerFrancois Tremblayen_US
dc.contributor.thesis-supervisorWilliam Baldridgeen_US
dc.date.accessioned2012-09-06T12:15:13Z
dc.date.available2012-09-06T12:15:13Z
dc.date.defence2012-08-20
dc.date.issued2012-09-06
dc.description.abstractRetinal ganglion cells (RGCs) undergo continued maturation after birth. RGC development can be influenced by light, but for most RGCs this requires the development of functional retinal circuits that occurs up to 2 weeks after birth. A subpopulation of RGCs express melanopsin (MRGCs) making them intrinsically photosensitive at birth. I hypothesized that this intrinsic photosensitivity could affect the morphology of MRGCs during the postnatal (PN) developmental period (PN 3 to adult). I took advantage of the Clomeleon-expressing transgenic mouse line that, combined with melanopsin immunohistochemistry, allowed for the systematic identification of the M2 MRGC at different PN periods. The pattern of development of the M2 MRGC, characterized through the analysis of 6 morphological parameters, was similar to that described for other types of RGCs. Thus, despite being intrinsically photosensitive, M2 MRGCs did not show substantial developmental differences from other RGC typesen_US
dc.identifier.urihttp://hdl.handle.net/10222/15463
dc.language.isoenen_US
dc.subjectvisionen_US
dc.subjectretinaen_US
dc.subjectretinal ganglion cellsen_US
dc.subjectmelanopsinen_US
dc.subjectdevelopmenten_US
dc.titleCHARACTERIZATION AND DEVELOPMENT OF THE M2 MELANOPSIN RETINAL GANGLION CELL IN THE CLM-1 TRANSGENIC MOUSE RETINAen_US

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