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Characterization of Cux2 in the Developing Cerebellum

dc.contributor.authorCapaldo, Emily
dc.contributor.copyright-releaseNot Applicableen_US
dc.contributor.degreeMaster of Scienceen_US
dc.contributor.departmentDepartment of Medical Neuroscienceen_US
dc.contributor.ethics-approvalReceiveden_US
dc.contributor.external-examinern/aen_US
dc.contributor.graduate-coordinatorKazue Sembaen_US
dc.contributor.manuscriptsNot Applicableen_US
dc.contributor.thesis-readerWilliam Baldridgeen_US
dc.contributor.thesis-readerJames Fawcetten_US
dc.contributor.thesis-supervisorAngelo Iulianellaen_US
dc.date.accessioned2015-12-11T17:49:10Z
dc.date.available2015-12-11T17:49:10Z
dc.date.defence2015-11-27
dc.date.issued2015
dc.description.abstractA goal of developmental neurobiology is to understand the mechanisms involved in generating a mature nervous system. For example, researchers are trying to elucidate the processes of fate restriction, migration and maturation of neurons in the cerebellum. Specifically, it is unclear whether progenitors are fate restricted early in development or whether they become progressively fate restricted. Furthermore, Cux2 defines subsets of progenitors in multiple regions of the nervous system. Therefore, this study investigated the role of Cux2 in the developing cerebellum. Results revealed that Cux2 activity was restricted to the developing rhombic lip and choroid plexus, and that these cells were fated to became granule cells. However, the final set of experiments suggests that Cux2 is not capable of altering the fate of cerebellar progenitors. These results highlight that within the developing cerebellum Cux2 defines a subset of progenitors that are restricted to a granule cell fate.en_US
dc.identifier.urihttp://hdl.handle.net/10222/64669
dc.language.isoenen_US
dc.subjectNeuroscienceen_US
dc.subjectDevelopmenten_US
dc.titleCharacterization of Cux2 in the Developing Cerebellumen_US

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