dc.contributor.author | Mahmud-Al-Rafat, Abdullah | |
dc.date.accessioned | 2023-04-04T18:24:21Z | |
dc.date.available | 2023-04-04T18:24:21Z | |
dc.date.issued | 2023-03-14 | |
dc.identifier.uri | http://hdl.handle.net/10222/82357 | |
dc.description.abstract | Since the beginning of coronavirus disease-19 (COVID-19) pandemic many efforts were made to explore the role of interleukin-6 (IL-6) in COVID-19. I used severe non-COVID-19 to better understand the IL-6 signaling in severe COVID-19. I assess plasma concentration of twenty-five biomarkers in severe COVID-19 patients and showed interaction of pro-inflammatory biomarkers with IL-6. I further investigate the interaction between IL-6 signaling components [IL-6, soluble IL-6 receptor (sIL-6R) and soluble glycoprotein 130 (sgp130)] and explain the type of IL-6 signaling in severe COVID-19 and non-COVID-19 patients. A prediction model was also applied to classify the disease group based on performance of IL-6 biomarkers individually and together. My data provide evidence of differential IL-6 signaling in two the different severe disease models. Notably, from this study, it is evident that severe COVID-19 is characterized by dysregulated IL-6 trans-signaling while severe non-COVID-19 followed a pattern of IL-6 classical-signaling. | en_US |
dc.language.iso | en_US | en_US |
dc.subject | COVID-19 | en_US |
dc.subject | Interleukin-6 | en_US |
dc.subject | SARS-CoV-2 | en_US |
dc.subject | Cytokine | en_US |
dc.title | CHARACTERIZING THE TYPE OF INTERLEUKIN-6 SIGNALING IN SEVERE COVID-19 | en_US |
dc.date.defence | 2023-03-14 | |
dc.contributor.department | Department of Microbiology & Immunology | en_US |
dc.contributor.degree | Master of Science | en_US |
dc.contributor.external-examiner | n/a | en_US |
dc.contributor.graduate-coordinator | Zhenyu Cheng | en_US |
dc.contributor.thesis-reader | Chris Richardson | en_US |
dc.contributor.thesis-reader | Jason LeBlanc | en_US |
dc.contributor.thesis-reader | Alyson Kelvin | en_US |
dc.contributor.thesis-supervisor | David Kelvin | en_US |
dc.contributor.ethics-approval | Received | en_US |
dc.contributor.manuscripts | Not Applicable | en_US |
dc.contributor.copyright-release | No | en_US |