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dc.contributor.authorSimmons, Maria
dc.date.accessioned2019-12-12T15:57:13Z
dc.date.available2019-12-12T15:57:13Z
dc.identifier.urihttp://hdl.handle.net/10222/76777
dc.description.abstractDissociation is characterized by either heightened sensitivity to emotions (under-modulation) or dampened experience of emotions (over-modulation) (Krause-Utz & Elzinga, 2018; Lanius et al., 2010). Within fMRI studies, over- and under-modulation have been associated with differing functional connectivity when patients are exposed to memories of traumatic events (Krause-Utz et al., 2018; Ludӓscher et al., 2010; Winter et al., 2016). This study included female patients with Borderline Personality Disorder taking part in a 6-week treatment program to examine the interactions between changes in symptoms (n=13) and connectivity (n=12) pre- and post-treatment. Results suggest all symptom measures had significant changes from pre- to post-treatment. Changes in symptoms did not relate to changes of functional connectivity from pre- to post-treatment, but differing neurobiology was observed between under- and over-modulation. Furthermore, the amygdala appears to be co-activated with the nucleus accumbens, hippocampus, postcentral gyrus, dorsolateral middle temporal gyrus and precentral gyrus during mood induction tasks.en_US
dc.language.isoenen_US
dc.subjectBorderline Personality Disorderen_US
dc.subjectFunctional Connectivityen_US
dc.subjectfMRIen_US
dc.subjectSymptom Severityen_US
dc.titleFUNCTIONAL CONNECTIVITY, SYMPTOM SEVERITY AND TREATMENT OUTCOMES IN WOMEN WITH BORDERLINE PERSONALITY DISORDERen_US
dc.date.defence2019-12-02
dc.contributor.departmentDepartment of Psychiatry Researchen_US
dc.contributor.degreeMaster of Scienceen_US
dc.contributor.external-examinerDr. Derek Fisheren_US
dc.contributor.graduate-coordinatorDr. Sherry Stewarten_US
dc.contributor.thesis-readerDr. Joel Townen_US
dc.contributor.thesis-readerDr. Aaron Newmanen_US
dc.contributor.thesis-supervisorDr. Phil Tibboen_US
dc.contributor.thesis-supervisorDr. Jackie Kinleyen_US
dc.contributor.ethics-approvalReceiveden_US
dc.contributor.manuscriptsNot Applicableen_US
dc.contributor.copyright-releaseNot Applicableen_US
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