dc.contributor.author | Legge, Alexandra | |
dc.date.accessioned | 2019-11-28T16:07:13Z | |
dc.date.available | 2019-11-28T16:07:13Z | |
dc.date.issued | 2019-11-28T16:07:13Z | |
dc.identifier.uri | http://hdl.handle.net/10222/76689 | |
dc.description.abstract | For patients with systemic lupus erythematosus (SLE), clinical outcomes are highly variable and challenging to predict. Such differences in susceptibility to adverse health outcomes can be quantified using a frailty index (FI). We used data from an international cohort of recently-diagnosed SLE patients to construct and validate the first FI for patients with SLE, to be known as the SLICC-FI. We assessed whether the SLICC-FI was predictive of future adverse health outcomes including hospitalizations, organ damage and mortality, after adjustment for the SLICC/ACR Damage Index (SDI), a known prognostic factor in SLE. Higher baseline SLICC-FI scores were associated with more hospitalizations, increased organ damage accrual, and increased mortality risk during follow-up. For all three outcomes, the SLICC-FI improved prediction when compared to the SDI alone. The SLICC-FI holds potential value in quantifying vulnerability among patients with SLE and provides additional prognostic information when compared to existing SLE measures. | en_US |
dc.language.iso | en | en_US |
dc.subject | Frailty | en_US |
dc.subject | Systemic lupus erythematosus | en_US |
dc.title | Constructing and validating a frailty index as a novel health measure in systemic lupus erythematosus | en_US |
dc.date.defence | 2018-07-18 | |
dc.contributor.department | Department of Community Health & Epidemiology | en_US |
dc.contributor.degree | Master of Science | en_US |
dc.contributor.external-examiner | N/A | en_US |
dc.contributor.graduate-coordinator | Kathy MacPherson | en_US |
dc.contributor.thesis-reader | Pantelis Andreou | en_US |
dc.contributor.thesis-reader | Kenneth Rockwood | en_US |
dc.contributor.thesis-supervisor | John G. Hanly | en_US |
dc.contributor.thesis-supervisor | Susan Kirkland | en_US |
dc.contributor.ethics-approval | Received | en_US |
dc.contributor.manuscripts | Yes | en_US |
dc.contributor.copyright-release | Yes | en_US |