dc.contributor.author | Rockwood, Kenneth | |
dc.contributor.author | Fay, Sherri | |
dc.contributor.author | Gorman, Mary | |
dc.contributor.author | Carver, Daniel | |
dc.contributor.author | Graham, Janice | |
dc.date.accessioned | 2019-05-21T12:54:27Z | |
dc.date.available | 2019-05-21T12:54:27Z | |
dc.date.issued | 2007-08-30 | |
dc.identifier.citation | Rockwood, K., Fay, S., Gorman, M., Carver, D., & Graham, J. E. (2007). The clinical meaningfulness of ADAS-Cog changes in Alzheimer's disease patients treated with donepezil in an open-label trial. BMC Neurology, 7(1), 26. doi:10.1186/1471-2377-7-26 | en_US |
dc.identifier.uri | http://hdl.handle.net/10222/75690 | |
dc.description.abstract | Background: In 6-month anti-dementia drug trials, a 4-point change in the Alzheimer's Disease Assessment Scale-Cognitive Subscale (ADAS-Cog) is held to be clinically important. We examined how this change compared with measures of clinical meaningfulness.
Methods: This is a secondary analysis of a 12 month open-label study of 100 patients (71 women) diagnosed with mild to moderate AD treated with 5–10 mg of donepezil daily. We studied the observed case, 6-month change from baseline on the ADAS-Cog, the Clinician's Interview Based Impression of Change-Plus Caregiver Input (CIBIC-Plus), patient-Goal Attainment Scaling (PGAS) and clinician-GAS (CGAS).
Results: At 6 months, donepezil-treated patients (n = 95) were more likely to show no change (+/ - 3 points) on the ADAS-Cog (56%) than to improve (20%) or decline (24%) by 4-points. ADAS- Cog change scores were little correlated with other measures: from -0.09 for PGAS to 0.27 for the CIBIC-Plus. While patients who improved on the ADAS-Cog were less likely to decline on the clinical measures (26%), 43% of patients who declined on the ADAS-Cog improved on at least two of the clinical measures.
Conclusion: The ADAS-Cog did not capture all clinically important effects. In general, ADAS-Cog improvement indicates clinical improvement, whereas many people with ADAS-Cog decline do not show clinical decline. The open-label design of this study does not allow us to know whether this is a treatment effect, which requires further investigation. | en_US |
dc.publisher | BMC Springer Nature | en_US |
dc.relation.ispartof | BMC Neurology | en_US |
dc.title | The clinical meaningfulness of ADAS-Cog changes in Alzheimer’s disease patients treated with donepezil in an open-label trial | en_US |
dc.type | Text | en_US |