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dc.contributor.authorSy, Jezreel Justine
dc.date.accessioned2019-05-01T10:49:46Z
dc.date.available2019-05-01T10:49:46Z
dc.identifier.urihttp://hdl.handle.net/10222/75666
dc.description.abstractThe scotopic threshold response (STR) of the electroretinogram (ERG) is thought to measure inner retinal function, specifically retinal ganglion cells (RGCs). However, the degree to which the STR is masked by the larger amplitudes of outer retinal function is not known. Light-induced retinal damage (LIRD) was used to selectively cause photoreceptor death in pigmented and albino mice to examine whether the effects of phototoxicity extend beyond photoreceptors. In pigmented mice, there was no structural loss measured with optical coherence tomography over a 121-day period, however, there was a decrease in ERG function. In albino mice, we found retinal thickness loss over a 73-day period, which correlated with the much larger decrease in outer retinal function. No RGC loss was observed with either strain. Changes in inner retinal function are much larger in albino compared to pigmented mice despite no structural loss, suggesting that there are other underlying mechanisms affecting the RGC function indirectly via the loss of photoreceptors, and thereby the generation of the STR.en_US
dc.language.isoen_USen_US
dc.subjectRetinal ganglion cellen_US
dc.subjectLight-induced retinal damageen_US
dc.subjectElectroretinogramen_US
dc.subjectScotopic threshold responseen_US
dc.titleFUNCTIONAL RETINAL GANGLION CELL ACTIVITY FOLLOWING LIGHT-INDUCED RETINAL DAMAGE IN MICEen_US
dc.date.defence2019-03-21
dc.contributor.departmentDepartment of Clinical Vision Scienceen_US
dc.contributor.degreeMaster of Scienceen_US
dc.contributor.external-examinern/aen_US
dc.contributor.graduate-coordinatorDarren Oystrecken_US
dc.contributor.thesis-readerFrancois Tremblayen_US
dc.contributor.thesis-readerNathan Crowderen_US
dc.contributor.thesis-readerJeremy Murphyen_US
dc.contributor.thesis-supervisorBalwantray Chauhanen_US
dc.contributor.ethics-approvalReceiveden_US
dc.contributor.manuscriptsNot Applicableen_US
dc.contributor.copyright-releaseNot Applicableen_US
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