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dc.contributor.authorRelja, Nicholas
dc.date.accessioned2019-01-15T18:55:16Z
dc.date.available2019-01-15T18:55:16Z
dc.identifier.urihttp://hdl.handle.net/10222/75079
dc.description.abstractBreast cancer is the most common form of cancer in Canadian women. Despite numerous therapeutic options, multidrug resistance (MDR) remains an obstacle to successful therapy. Jadomycins are natural products derived from the soil bacteria Streptomyces venezuelae ISP5230 and maintain cytotoxicity in multidrug resistant human breast cancer cell lines. The objectives were to determine the single dose pharmacokinetics and safety of jadomycins and their effects on 4T1 breast primary tumors and lung metastasis in mice. In the pharmacokinetic studies, intraperitoneal-administered jadomycins B, S, and F were rapidly absorbed, achieved serum concentration in the predicted therapeutic range and had a biphasic distribution and elimination profile. In tumor studies jadomycin B partially reduced tumor volumes and lung metastasis. In conclusion, jadomycins are safe to administer chronically to mice at doses up to 13.8 mg/kg twice daily. The partial anti-tumor and anti-metastatic effects of jadomycin B were encouraging results and require further study.en_US
dc.language.isoenen_US
dc.subjectbreast canceren_US
dc.subjectjadomycinsen_US
dc.subjectbalb/c miceen_US
dc.subjectnatural productsen_US
dc.subjectmultidrug resistanceen_US
dc.subject4T1en_US
dc.titleSTUDY OF JADOMYCIN PHARMACOKINETICS AND ANTI-BREAST CANCER ACTIVITY IN BALB/C MICEen_US
dc.date.defence2017-12-08
dc.contributor.departmentCollege of Pharmacyen_US
dc.contributor.degreeMaster of Scienceen_US
dc.contributor.external-examinerDr. Paola Marcatoen_US
dc.contributor.graduate-coordinatorDr. David Jakemanen_US
dc.contributor.thesis-readerDr. Pollen Yeungen_US
dc.contributor.thesis-supervisorDr. Kerry Goralskien_US
dc.contributor.ethics-approvalReceiveden_US
dc.contributor.manuscriptsNot Applicableen_US
dc.contributor.copyright-releaseNot Applicableen_US
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