Photo-induced Anticancer Activity and Singlet Oxygen Production of Prodigiosenes
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Date
2018Author
Savoie, Huguette
Figliola, Carlotta
Marchal, Estelle
Crabbe, Bry W.
Hallett-Tapley, Geniece L.
Boyle, Ross W.
Thompson, Alison
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The photo-induced cytotoxicity of prodigiosenes is reported. One prodigiosene represents a synthetic analogue of the natural product prodigiosin, and two are conjugated to molecules that target the estrogen receptor (ER). A comparison of incubation and irradiation frameworks for the three prodigiosenes is reported, with activity against ER- and ER+ lines explored. Furthermore, the ability of the three prodigiosenes to photosensitise the production of singlet oxygen is demonstrated, shedding mechanistic light onto possible photodynamic therapeutic effects of this class of tripyrroles.
Citation
Savoie, H., Figliola, C., Marchal, E., Crabbe, B. W., Hallett-Tapley, G. L., Boyle, R. W., & Thompson, A. (2018). Photo-induced anticancer activity and singlet oxygen production of prodigiosenes. Photochemical & Photobiological Sciences, 17(5), 599-606.
DOI: 10.1039/C8PP00060