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dc.contributor.authorCarew, Allie
dc.date.accessioned2018-08-17T14:15:23Z
dc.date.available2018-08-17T14:15:23Z
dc.identifier.urihttp://hdl.handle.net/10222/74120
dc.description.abstractThis retrospective cohort study quantified the risk of subsequent cardiovascular disease (CVD) associated with gestational diabetes mellitus (GDM) and estimated the extent to which type 2 diabetes mellitus (T2DM) mediates this association. Cox regression models were used to quantify the association between GDM and CVD, while mediation analysis was used to determine whether T2DM mediates this association. Analyses used data from a linkage of the Nova Scotia Atlee Perinatal Database with administrative health databases. Among a total of 87,632 women who were included, 4.0% experienced GDM in at least one pregnancy. Women were followed for a median of 11.8 years and 1.4% developed CVD. Compared with women who did not have GDM, women with GDM had a higher risk of developing CVD [adjusted HR=1.53 (95% CI 1.23-1.91)]. T2DM mediated 93.9% of this association. These results support screening and counseling women with prior GDM to improve cardiovascular health.en_US
dc.language.isoenen_US
dc.subjectGestational Diabetes Mellitusen_US
dc.subjectType 2 Diabetes Mellitusen_US
dc.subjectCardiovascular Diseaseen_US
dc.subjectMediation Analysisen_US
dc.titleTHE ASSOCIATION BETWEEN GESTATIONAL DIABETES MELLITUS AND CARDIOVASCULAR DISEASE AND POSSIBLE MEDIATION BY TYPE 2 DIABETES MELLITUSen_US
dc.date.defence2018-08-09
dc.contributor.departmentDepartment of Community Health & Epidemiologyen_US
dc.contributor.degreeMaster of Scienceen_US
dc.contributor.external-examinerN/Aen_US
dc.contributor.graduate-coordinatorDr. Kathleen MacPhersonen_US
dc.contributor.thesis-readerDr. Stefan Kuhleen_US
dc.contributor.thesis-readerDr. Linda Doddsen_US
dc.contributor.thesis-readerDr. Susan Kirklanden_US
dc.contributor.thesis-supervisorDr. Christy Woolcotten_US
dc.contributor.ethics-approvalReceiveden_US
dc.contributor.manuscriptsNot Applicableen_US
dc.contributor.copyright-releaseNot Applicableen_US
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