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dc.contributor.authorGatien, Alexandre
dc.date.accessioned2018-06-06T14:00:01Z
dc.date.available2018-06-06T14:00:01Z
dc.identifier.urihttp://hdl.handle.net/10222/73959
dc.description.abstractNotwithstanding the utility of Buchwald-Hartwig Amination (BHA) technology, the cost and scarcity of palladium has prompted a move to base metal catalysis in recent years. Nickel has emerged as a prime candidate in this chemistry to compete with palladium, being both cheap and abundant. Amination chemistry with nickel is relatively unexplored, and the distinct electronic properties of nickel offer reactivity benefits over palladium when employing challenging phenol derived electrophiles. While ligand design requirements for BHA chemistry are well-understood, structure-reactivity trends for nickel counterparts are ill-defined, with few ligands capable of promoting these nickel-catalyzed cross-couplings. Following the establishment of PAd-DalPhos as the state-of-the-art ligand in challenging nickel-catalyzed amination reactions, we sought to build on this ortho phenylene bridged motif and explore new architectures encompassing a bulky, modestly electron-donating bisphosphine framework which would favour reductive elimination, the presumed rate-limiting step in the catalytic cycle.en_US
dc.language.isoenen_US
dc.subjectCataysisen_US
dc.subjectNickelen_US
dc.subjectAminationen_US
dc.subjectCross-couplingen_US
dc.subjectN-heterocyclic phosphineen_US
dc.titleN-Heterocyclic Bisphosphine Ligands For Use In Nickel-Catalyzed C(sp2)-N Cross-Couplingen_US
dc.date.defence2018-06-05
dc.contributor.departmentDepartment of Chemistryen_US
dc.contributor.degreeMaster of Scienceen_US
dc.contributor.external-examinern/aen_US
dc.contributor.graduate-coordinatorDr. Mark Stradiottoen_US
dc.contributor.thesis-readerDr. Mita Dasogen_US
dc.contributor.thesis-readerDr. Laura Turculeten_US
dc.contributor.thesis-supervisorDr. Mark Stradiottoen_US
dc.contributor.thesis-supervisorDr. Alex Speeden_US
dc.contributor.ethics-approvalNot Applicableen_US
dc.contributor.manuscriptsYesen_US
dc.contributor.copyright-releaseYesen_US
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