dc.contributor.author | Hickey, Megan | |
dc.date.accessioned | 2018-02-12T17:14:38Z | |
dc.date.available | 2018-02-12T17:14:38Z | |
dc.date.issued | 2018-02-12T17:14:38Z | |
dc.identifier.uri | http://hdl.handle.net/10222/73604 | |
dc.description.abstract | Programmed death ligand 1 (PD-L1) is a T cell inhibitory molecule expressed by activated T cells and antigen presenting cells, as well as by various tumor types. PD-L1 expression is believed to contribute to immune evasion by breast cancer cells. The goal of this investigation was to determine the effect of the phytochemical apigenin on PD-L1 expression by several breast cancer cell lines. Apigenin inhibited both IFN-?- and IFN-?-induced upregulation of PD-L1 by various breast cancer cell lines but did not affect constitutive PD-L1 expression. Apigenin also inhibited IFN-?-induced STAT1 phosphorylation. Apigenin-mediated reduction of IFN-?-induced PD-L1 expression by breast cancer cells increased Jurkat T cell proliferation in the presence of breast cancer cells. These data show that apigenin inhibits IFN-induced PD-L1 expression by breast cancer cells. Therefore, apigenin may act as an immunomodulator that increases the vulnerability of breast cancer cells to anti-tumor immune responses. | en_US |
dc.language.iso | en | en_US |
dc.subject | Apigenin | en_US |
dc.subject | Programmed Death Ligand 1 | |
dc.subject | Immunotherapy | |
dc.subject | Breast Cancer | |
dc.subject | T Cell | |
dc.title | The Flavonoid Apigenin Inhibits Inducible Programmed Death Ligand 1 Expression by Breast Cancer Cells | en_US |
dc.date.defence | 2012-07-23 | |
dc.contributor.department | Department of Microbiology & Immunology | en_US |
dc.contributor.degree | Master of Science | en_US |
dc.contributor.external-examiner | Dr. Robert Liwski | en_US |
dc.contributor.graduate-coordinator | Dr. Roy Duncan | en_US |
dc.contributor.thesis-reader | Dr. Brent Johnston | en_US |
dc.contributor.thesis-reader | Dr. Jun Wang | en_US |
dc.contributor.thesis-supervisor | Dr. David Hoskin | en_US |
dc.contributor.ethics-approval | Not Applicable | en_US |
dc.contributor.manuscripts | Not Applicable | en_US |
dc.contributor.copyright-release | Not Applicable | en_US |