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dc.contributor.authorMartin, Laura
dc.date.accessioned2018-01-05T19:18:04Z
dc.date.available2018-01-05T19:18:04Z
dc.identifier.urihttp://hdl.handle.net/10222/73553
dc.description.abstractCholesterol is an essential component of cell membranes and plays important roles in cell signalling. The brain contains a quarter of the body’s total cholesterol pool, all of which is synthesized in situ by neurons and glia, which are the structurally and functionally distinct cells of the brain. Neurons synthesize large quantities of cholesterol during development, but rely more so on glial synthesis in the adult brain. Yet neuronal cholesterol synthesis is maintained into maturity, suggesting a specific role for this process. Oxysterol-binding protein-related protein 4 (ORP4) is highly expressed in the hippocampus, and binds and transfers cholesterol and phosphatidylinositol-4-phosphate in vitro. I investigated the roles of neuronal cholesterol biosynthesis and ORP4 in hippocampal cells. My findings implicate neuronal cholesterol synthesis in regulating spine density and provide evidence for a role of ORP4 in glial proliferation, mitochondrial morphology, and the regulation of neuronal proteins involved in mitochondrial homeostasis.en_US
dc.language.isoenen_US
dc.subjectcholesterolen_US
dc.subjectORP4en_US
dc.subjectneuronen_US
dc.subjectgliaen_US
dc.subjectdendritic spineen_US
dc.subjectmitochondriaen_US
dc.titleCharacterization of the roles of neuronal cholesterol biosynthesis and ORP4 in hippocampal neurons and gliaen_US
dc.date.defence2016-10-31
dc.contributor.departmentDepartment of Biochemistry & Molecular Biologyen_US
dc.contributor.degreeMaster of Scienceen_US
dc.contributor.external-examinern/aen_US
dc.contributor.graduate-coordinatorDr Jan Raineyen_US
dc.contributor.thesis-readerDr Neale Ridgwayen_US
dc.contributor.thesis-readerDr Eileen Denovan-Wrighten_US
dc.contributor.thesis-readerDr Petra Kienesbergeren_US
dc.contributor.thesis-supervisorDr Barbara Kartenen_US
dc.contributor.ethics-approvalReceiveden_US
dc.contributor.manuscriptsNot Applicableen_US
dc.contributor.copyright-releaseNot Applicableen_US
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