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dc.contributor.authorXu, Wei
dc.date.accessioned2017-12-08T18:54:03Z
dc.date.available2017-12-08T18:54:03Z
dc.identifier.urihttp://hdl.handle.net/10222/73471
dc.description.abstractChitin, the second most abundant polysaccharide and its derivatives are known to have hypocholesterolaemic properties. In this study, chitin (~96.4% purity) extracted from lobster shells was converted to chitosan, with a high degree of deacetylation (DD, 90.9%) and a molecular weight (MW) of >500 kDa. The prepared chitooligosaccharides (COS) had a net positive surface charge of +37.6 mV, bimodal MW distribution (8.8 kDa and 0.6 kDa), and showed the highest bile acid-binding capacity against sodium deoxycholate (SDC) at the highest concentration (50 mg/mL). Results from this study suggest COS bind to bile acids by multiple different mechanisms; in fact, COS exhibited more complex binding than that of chitin and chitosan. The findings in this study will be useful in understand the hypocholesterolaemic properties of chitin and its derivatives. However, further studies elucidating the relationship between physicochemical properties of chitin and its derivatives and their bile acid-binding effects are essential.en_US
dc.language.isoenen_US
dc.subjectlobster shellsen_US
dc.subjectchitinen_US
dc.subjectchitosanen_US
dc.subjectchitooligosaccharidesen_US
dc.subjecthypocholesterolaemic propertiesen_US
dc.subjectbile acid-binding capacityen_US
dc.titleBile acid-binding capacity of lobster shell-derived chitin, chitosan and chitooligosaccharidesen_US
dc.date.defence2017-11-14
dc.contributor.departmentFaculty of Agricultureen_US
dc.contributor.degreeMaster of Scienceen_US
dc.contributor.external-examinerDr. Su-Ling Brooksen_US
dc.contributor.graduate-coordinatorDr. Haibo Niuen_US
dc.contributor.thesis-readerDr. Chibuike Udenigween_US
dc.contributor.thesis-readerDr. Stephanie Collinsen_US
dc.contributor.thesis-supervisorDr. Beth Masonen_US
dc.contributor.thesis-supervisorDr. Nancy Pittsen_US
dc.contributor.ethics-approvalNot Applicableen_US
dc.contributor.manuscriptsNot Applicableen_US
dc.contributor.copyright-releaseNot Applicableen_US
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