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dc.contributor.authorSmith, Nathan Kyle
dc.date.accessioned2017-09-01T14:51:07Z
dc.date.available2017-09-01T14:51:07Z
dc.identifier.urihttp://hdl.handle.net/10222/73260
dc.description.abstractWith the support of Atlantic PATH, this study has used the world’s largest collection of toenail samples to investigate the association between chronic disease and arsenic speciation. The results of our study showed no difference in total arsenic body burden between healthy individuals and those with type II diabetes, or skin, lung, bladder, or kidney cancer. However, there was a statistically significant difference in the composition of arsenic between the groups. Specifically, a higher proportion of monomethylarsenic acid (MMA) was found in the disease groups, compared to healthy individuals. This is the first study to investigate chronic disease using arsenic speciation in toenails, a non-invasive, biobankable, longer-term biomarker. These preliminary data provide solid evidence that toenail arsenic speciation research in the context of chronic disease is both feasible, and could potentially have important implications for health.en_US
dc.language.isoenen_US
dc.subjectEnvironmental Epidemiologyen_US
dc.subjectArsenic Speciationen_US
dc.subjectBiomarkersen_US
dc.subjectToenailsen_US
dc.titleInvestigating the Association between Arsenic Exposure and Chronic Disease Using Toenail Speciation Biomarkers: A Pilot Study in Atlantic Canadaen_US
dc.date.defence2017-08-16
dc.contributor.departmentDepartment of Community Health & Epidemiologyen_US
dc.contributor.degreeMaster of Computer Scienceen_US
dc.contributor.external-examinern/aen_US
dc.contributor.graduate-coordinatorKathleen MacPhersonen_US
dc.contributor.thesis-readerKathleen MacPhersonen_US
dc.contributor.thesis-readerSwarna Weerasingheen_US
dc.contributor.thesis-supervisorJong Sung Kimen_US
dc.contributor.ethics-approvalReceiveden_US
dc.contributor.manuscriptsNoen_US
dc.contributor.copyright-releaseNoen_US
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