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dc.contributor.authorShakshuki, Ayah
dc.date.accessioned2017-08-15T17:32:48Z
dc.date.available2017-08-15T17:32:48Z
dc.identifier.urihttp://hdl.handle.net/10222/73108
dc.description.abstractNeuropathic pain affects a significant portion of the population. It is chronic in duration, and resistant to many conventional oral analgesics. Topical gabapentin and amitriptyline in various strengths and bases have been compounded by specialized pharmacies for years. Although there is some evidence of efficacy in the literature, there are also controversies as well because of lack of drug release, permeation and stability data. In this thesis, stability of amitriptyline and gabapentin in three different commonly used topical bases were investigated at three different temperatures over a 90-day period. In vitro drug release and permeation studies were also conducted using Franz diffusion cells. Data from these studies provided new evidence that will improve compounding services for neuropathic pain and patients’ quality of life.en_US
dc.language.isoen_USen_US
dc.subjectNeuropathic painen_US
dc.subjectTopical Amitriptylineen_US
dc.subjectTopical Gabapentinen_US
dc.subjectStabilityen_US
dc.subjectDrug Releaseen_US
dc.subjectDrug Permeationen_US
dc.subjectCompoundingen_US
dc.titleTOPICAL FORMULATIONS FOR NEUROPATHIC PAINen_US
dc.typeThesisen_US
dc.date.defence2017-07-28
dc.contributor.departmentCollege of Pharmacyen_US
dc.contributor.degreeMaster of Scienceen_US
dc.contributor.external-examinern/aen_US
dc.contributor.graduate-coordinatorDavid Jakemanen_US
dc.contributor.thesis-readerTannis Jurgensen_US
dc.contributor.thesis-readerPollen Yeungen_US
dc.contributor.thesis-supervisorRemigius Aguen_US
dc.contributor.ethics-approvalNot Applicableen_US
dc.contributor.manuscriptsNot Applicableen_US
dc.contributor.copyright-releaseNot Applicableen_US
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