Show simple item record

dc.contributor.authorForsythe, Marika
dc.date.accessioned2016-12-22T13:14:56Z
dc.date.available2016-12-22T13:14:56Z
dc.identifier.urihttp://hdl.handle.net/10222/72613
dc.description.abstractPersonalized therapies against lung cancer provide more efficient treatment options than conventional therapies, as they target the genetic makeup. Current treatment options are available against EGFR or ALK genes mutations. 667 cases of surgically resected lung cancer underwent molecular analysis for six possible gene mutations, including EGFR, KRAS, BRAF, PIK3CA, HER2 and ALK. The samples included different types of non-small-cell lung cancer. The highest mutation frequency was the KRAS mutation (24.4%) while the lowest was the HER2 mutation (0%). The significant correlations observed were: against age, where fewer older patients exhibited BRAF mutations; against gender, where females exhibited more EGFR mutations; against cell type, where adenocarcinoma exhibited more KRAS and EGFR mutations; against vascular invasion, where positive individuals had fewer EGFR mutations; against smoking history, where non-smokers exhibited more EGFR mutations. This study provides significant results for better understanding the gene mutation status and their significance in lung cancer patients.en_US
dc.language.isoenen_US
dc.subjectLungs--Cancer.en_US
dc.subjectPersonalized medicineen_US
dc.titleThe Molecular Profiling of Non-Small Cell Lung Canceren_US
dc.date.defence2016-12-14
dc.contributor.departmentDepartment of Pathologyen_US
dc.contributor.degreeMaster of Scienceen_US
dc.contributor.external-examinerDr. Carmen Giacomantonioen_US
dc.contributor.graduate-coordinatorDr. Wenda Greeren_US
dc.contributor.thesis-readerDr. Karen Bedarden_US
dc.contributor.thesis-readerDr. Gordon Flowerdewen_US
dc.contributor.thesis-supervisorDr. Zhaolin Xuen_US
dc.contributor.thesis-supervisorDr. Wenda Greeren_US
dc.contributor.ethics-approvalReceiveden_US
dc.contributor.manuscriptsNot Applicableen_US
dc.contributor.copyright-releaseNot Applicableen_US
 Find Full text

Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record